182066-23-5Relevant articles and documents
Design, synthesis and binding affinities of novel non-peptide mimics of somatostatin/Sandostatin
Damour, Dominique,Barreau, Michel,Blanchard, Jean-Charles,Burgevin, Marie-Claude,Doble, Adam,Herman, Frederic,Pantel, Guy,James-Surcouf, Evelyne,Vuilhorgne, Marc,Mignani, Serge,Poitout, Lydie,Le Merrer, Yves,Depezay, Jean-Claude
, p. 1667 - 1672 (2007/10/03)
Based on molecular modelling studies of Sandostatin, sugar-based derivatives I-VI were prepared as potential non-peptide mimics of somatostatin/Sandostatin. These compounds displaced 3-[125I]-Tyr11-SRIF-14 from the somatostatin receptor on membranes of rat cerebral cortex with IC50 values between 10 and 15 μM.