182066-01-9

Upstream product

• 36199-02-7 3,4-di-O-benzyl-D-mannitol 

Downstream Products

• 182066-23-5 3-{2-[(2S,3R,4R,5S)-3,4-Bis-benzyloxy-2-[(6-tert-butoxycarbonylamino-hexylamino)-methyl]-5-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-1-yl]-ethyl}-indole-1-carboxylic acid tert-butyl ester 
• 182066-27-9 3-{2-[(2S,3R,4S,5R)-3,4-Bis-benzyloxy-2-[(6-tert-butoxycarbonylamino-hexylamino)-methyl]-5-(tert-butyl-dimethyl-silanyloxy)-piperidin-1-yl]-ethyl}-indole-1-carboxylic acid tert-butyl ester 
• 182066-25-7 3-{2-[(2S,3R,4R,5S)-3,4-Bis-benzyloxy-5-(6-tert-butoxycarbonylamino-hexylamino)-2-(tert-butyl-dimethyl-silanyloxymethyl)-piperidin-1-yl]-ethyl}-indole-1-carboxylic acid tert-butyl ester 
• 184782-68-1 3-{2-[(2S,3R,4S,5R)-3,4-Bis-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-piperidin-1-yl]-ethyl}-indole-1-carboxylic acid tert-butyl ester 
• 182066-15-5 3-{2-[(2S,3R,4S,5R)-3,4-Bis-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2-methanesulfonyloxymethyl-piperidin-1-yl]-ethyl}-indole-1-carboxylic acid tert-butyl ester 
• 182066-10-0 3-{2-[(2S,3R,4S,5R)-3,4-Bis-benzyloxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-methanesulfonyloxy-piperidin-1-yl]-ethyl}-indole-1-carboxylic acid tert-butyl ester 
• 182066-12-2 3-{2-[(2S,3R,4R,5S)-5-Azido-3,4-bis-benzyloxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-piperidin-1-yl]-ethyl}-indole-1-carboxylic acid tert-butyl ester 
• 182066-08-6 3-{2-[(2S,3R,4S,5R)-3,4-Bis-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-piperidin-1-yl]-ethyl}-indole-1-carboxylic acid tert-butyl ester 
• 184781-26-8 3-{2-[(2S,3R,4R,5S)-5-Amino-3,4-bis-benzyloxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-piperidin-1-yl]-ethyl}-indole-1-carboxylic acid tert-butyl ester 
• 182066-06-4 3-{2-[(2S,3R,4R,5R)-3,4-Bis-benzyloxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-hydroxy-piperidin-1-yl]-ethyl}-indole-1-carboxylic acid tert-butyl ester 
• 182066-02-0 3-[2-((2S,3R,4R,5R)-3,4-Bis-benzyloxy-5-hydroxy-2-hydroxymethyl-piperidin-1-yl)-ethyl]-indole-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of azasugars as potent inhibitors of glycosidases

A series of enantiomerically pure azasugars (2,5-dideoxy-2,5-imino-D-mannitol, 1-deoxynojirimycin, 1-deoxymannojirimycin, and related compounds) was synthesized from D-mannitol via aminoheterocyclization of C2-symmetric bis-epoxides and subsequently followed by ring isomerization in few cases. These compounds have been evaluated as inhibitors of several glycosidases (α- and β-D-glucosidases, α-D-mannosidase and α-L-fucosidase). Inhibition studies indicate notably that the polyhydroxylated azepanes are inhibitors of glycosidases, with K(i) in the micromolar range.