1820675-44-2

Usage

Type

Chemical compound

Function

Potent and selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4)

Therapeutic Applications

Treatment of type 2 diabetes

Mechanism of Action

Regulates blood glucose levels by increasing the concentration of incretin hormones

Additional Studies

Investigated for potential effects on inflammation and immune response

Additional Studies

Investigated for potential to protect against kidney and cardiovascular complications associated with diabetes

Ongoing Research

Further research to better understand the full range of applications and potential benefits of 1-benzyl 3-(tert-butyl) (S)-pyrrolidine-1,3-dicarboxylate.

Upstream product

• 98946-18-0 tert-Butyl 2,2,2-trichloroacetimidate 
• 192214-00-9 (S)-1-((benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid 
• 192214-06-5 (R)-1-((benzyloxy)-carbonyl)pyrrolidine-3-carboxylic acid 

Relevant academic research and scientific papers

BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF

The present disclosure provides bifunctional compounds as HPK1 degraders via ubiquitin proteosome pathway, and method for treating diseases modulated by HPK1.

Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors

The molecular determinants for the activities of the reported benzoic acid (SH4-54), salicylic acid (BP-1-102), and benzohydroxamic acid (SH5-07)-based STAT3 inhibitors were investigated to design optimized analogues. All three leads are based on an N-met

2-ARYLSULFONAMIDO-N-ARYLACETAMIDE DERIVATIZED STAT3 INHIBITORS

The present disclosure provides pharmaceutical compositions comprising 2-arylsulfonamido-N-arylacetamide derivatized Stat3 inhibitors and certain pharmaceutically acceptable salts thereof, and methods of their use.