18207-47-1

Usage

Uses

Used in Chemical Synthesis:
Ethanone, 2,2,2-trifluoro-1-(2-furanyl)(9CI) is used as an intermediate in the chemical synthesis process for creating other chemical compounds. Its unique structure and reactivity make it a valuable component in the production of various substances.
Used in Pharmaceutical Industry:
Ethanone, 2,2,2-trifluoro-1-(2-furanyl)(9CI) is used as a building block in the development of pharmaceutical compounds. Its distinctive properties contribute to the creation of new drugs with potential therapeutic applications.
Used in Material Science:
Ethanone, 2,2,2-trifluoro-1-(2-furanyl)(9CI) is used as a component in the formulation of advanced materials. Its properties can influence the characteristics of materials, such as their stability, reactivity, and other physical or chemical attributes, making it suitable for various applications in material science.
Used in Research and Development:
Ethanone, 2,2,2-trifluoro-1-(2-furanyl)(9CI) is used as a research compound in scientific studies. Its unique structure and properties provide opportunities for exploring new chemical reactions, understanding molecular interactions, and advancing knowledge in the field of chemistry.

InChI:InChI=1/C6H3F3O2/c7-6(8,9)5(10)4-2-1-3-11-4/h1-3H

Upstream product

• 110-00-9 furan 
• 407-25-0 trifluoroacetic anhydride 
• 110-86-1 pyridine 
• 527-69-5 2-furancarbonyl chloride 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 98-01-1 furfural 
• 70783-48-1 2-(2,2,2-trifluoro-1-hydroxyethyl)furan 

Downstream Products

• 113452-65-6 (R)-2,2,2-Trifluoro-1-furan-2-yl-ethanol 
• 113452-66-7 (S)-2,2,2-Trifluoro-1-furan-2-yl-ethanol 
• 413600-00-7 (E)-2,2,2-trifluoro-1-(furan-2-yl)ethanone O-benzyloxime 
• 413599-92-5 (Z)-2,2,2-trifluoro-1-(furan-2-yl)ethanone O-benzyloxime 
• 65686-89-7 (Z)-2,2,2-trifluoro-1-(furan-2-yl)ethanone oxime 
• 413599-98-1 (E)-2,2,2-trifluoro-1-(furan-2-yl)ethanone oxime 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 202869-53-2 4-methoxy-N-(2,2,2-trifluoro-1-(furan-2-yl)ethylidene)aniline 
• 1333475-79-8 (S)-4-methoxy-N-(1,1,1-trifluoro-2-(furan-2-yl)-3-phenylpropan-2-yl)aniline 
• 1333475-80-1 4-methoxy-N-[(2S,3S)-1,1,1-trifluoro-2-(furan-2-yl)-3-phenylbutan-2-yl]aniline 
• 1333475-82-3 4-[(2S,3S)-1,1,1-trifluoro-2-(furan-2-yl)-3-phenylbutan-2-ylimino]cyclohexa-2,5-dienone 
• 1333475-83-4 tert-butyl (S)-1,1,1-trifluoro-2-(furan-2-yl)-3-phenylpropan-2-ylcarbamate 
• 1333475-84-5 tert-butyl (2S,3S)-1,1,1-trifluoro-2-(furan-2-yl)-3-phenylbutan-2-ylcarbamate 
• 1333475-81-2 C₁₉H₁₄F₃NO₂ 

Relevant academic research and scientific papers

A facile synthesis of aryl trifluoromethyl ketones

The reaction of arylcopper reagents with α,α,α-trifluoroacetic anhydride gives the corresponding aryl trifluoromethyl ketones in good yields.

Enantioselective Palladium-Catalyzed [3+2] Cycloaddition of Trimethylenemethane and Fluorinated Ketones

A nitrile-substituted trimethylenemethane (TMM) donor undergoes palladium-catalyzed [3+2] cycloadditions with fluorinated ketones to generate tetrasubstituted trifluoromethylated centers in high enantioselectivity under mild conditions. The generation of the palladium–TMM complex was achieved by a self-deprotonation strategy, which shows remarkable improvements in regiocontrol, efficiency, and atom economy of asymmetric [3+2] cycloadditions. Moreover, the versatility of the nitrile group provides direct access to a variety of synthetically useful intermediates, including amides, aldehydes, and esters. The developed reaction conditions allow for the synthesis of a wide variety of aromatic, heteroaromatic, and aliphatic fluorinated dihydrofurans in excellent regio- and enantioselectivities.

Enhancements of Trifluoroacetic Acylated Five-membered Heterocyclic Compounds Using as Additives in Dye Sensitized Solar Cells

In this study, five-membered heterocyclic compounds are trifluoroacetic acylated for the purpose of providing more long pairs to enhance electrolyte in dye sensitized solar cells (DSSCs). Four five-membered heterocyclic compounds will be trifluoroacetic acylated with trifluoroacetic anhydride by Friedel-Crafts acylation: furan, thiophene, pyrrole and N-methylpyrrole. The properties will be measured by cyclic voltage (CV), Fourier transform infrared spectroscopy (FTIR), solar simulator, and electrochemical impedance spectroscopy (EIS). We find out that furan and thiophene which we add in electrolyte as additives can increase short circuit current and photovoltaic efficiency, and furthermore, all the trifluoroacetic acylated heterocyclic compounds perform better photoelectric abilities than non-trifluoroacetic acylated one. The photovoltaic efficiency will be increased from 4.439% to 5.197% when 1wt% trifluoroacetic acylated thiophene is added in electrolyte as additives.

Silver compounds in synthetic chemistry. Part 5: Selective syntheses of trifluoromethylketones, RCOCF3, from trifluoromethylsilver, AgCF3, and corresponding acyl chlorides, RCOCl

Trifluoromethylketones of aromatics, heteroaromatics and olefins are formed selectively from reactions of trifluoromethylsilver and the corresponding carboxylic acid chlorides in moderate to excellent yields. The conditions chosen are dependent on the nature of the acyl chloride. Attempts to prepare alkyl(trifluoromethyl)ketones yielded product mixtures of the corresponding acyl fluorides, trifluoromethyl-, pentafluoroethyl- and n-heptafluoropropyl ketones.

THIADIAZOLES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of Formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and ischemia reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of Formula (IA).

ISOTHIAZOLE DIOXIDES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA): and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR50. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.

THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula (IA).

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

Die Reacktionen von Bis(perfluoralkyl)cadmium-Komplexen mit Arylcarbonsaeurechloriden: Synthese von Aryl(perfluoralkyl)ketonen, (Perfluoralkyl-dihydropyridin)arylcarbonsaeureamiden, α,α-Bis(trifluormethyl)benzylalkoholen und Benzoesaeure-α,α-bis(trifluormethyl)benzylestern

Perfluoroalkylcadmium complexes react with aroyl halides in the presence of strong bases such as pyridine to give the corresponding ketones ArCORf (which can be isolated in 5-51percent yield) and (perfluoroalkyldihydropyridine)aroylamides.The pure substances are obtained by chromatography.Aroyl fluorides and α,α-bis(trifluoromethyl)benzyl alcohols and benzoic acid-α,α-bis(trifluoromethyl)benzyl esters can be isolated as by-products.The dependency of the products formed on the kind of bases used as well as the reaction mechanisms are described.All products were identified by their 19F, 1H, 13C NMR, mass and IR spectra, and by elemental analysis.