182072-53-3

Upstream product

• 14550-93-7 5-O-cinnamoyl-9,10-isopropylidenetaxicine I 
• 1125-88-8 benzaldehyde dimethyl acetal 

Downstream Products

• 150930-83-9 7-deshydroxy baccatine III 
• 214192-74-2 7-deshydroxy-13-deshydro baccatine III 
• 182072-56-6 2,4,9,10,13-pentadesacetyl-1,2-O-benzylidene-9,10-O-isopropylidene-7-desacetoxy-13-oxo baccatine IV 
• 196404-39-4 2,9,10,13-tetradesacetyl-1,2-O-benzylidene-7-desacetoxy-9,10-O-isopropylidene-13-oxo baccatine IV 
• 196404-36-1 2,9,10,13-tetradesacetyl-1,2-O-benzylidene-7-desacetoxy-9,10-O-isopropylidene baccatine IV 
• 196404-40-7 7-desacetoxy-9,10,13-tridesacetyl-9,10-O-isopropylidene-13-oxo baccatine VI 
• 196404-41-8 1,2-O-benzylidene-4,20-dihydro-4α,20-dihydroxy-5-O-mesyl taxicine I 
• 196404-37-2 7-desacetoxy-9,10,13-tridesacetyl-9,10-O-isopropylidene baccatine VI 
• 196404-48-5 1,2-O-benzylidene-4,20-dihydro-4α,20-dihydroxy-5-O-mesyl-9-deshydro-10-acetyl taxicine I 
• 182208-88-4 1,2-O-benzylidene-9,10-O-isopropylidene-4,20-dihydro-4α,20-dihydroxy-20-O-terbutyldimethylsilyl taxicine I 
• 196404-42-9 1,2-O-benzylidene-4,20-dihydro-4α,20-dihydroxy-5-O-mesyl-20-O-terbutyldimethylsilyl taxicine I 
• 182072-55-5 1,2-O-benzylidene-9,10-O-isopropylidene-4,20-dihydro-4α,20-dihydroxy-20-O-terbutyldimethylsilyl-5-O-mesyl taxicine I 
• 196404-46-3 1,2-O-benzylidene-4,20-dihydro-4α,20-dihydroxy-5-O-mesyl-9-deshydro-10-acetyl-20-O-terbutyldimethylsilyl taxicine I 

Relevant academic research and scientific papers

Semisynthesis of flexible 5,7-dideoxypaclitaxel derivatives from Taxine B

Two new 5,7-dideoxypaclitaxel derivatives with flexible C-rings have been prepared starting from Taxine B, an alkaloid isolated from the leaves of Taxus baccata. Both derivatives lack the oxetane ring present in the antitumor agent paclitaxel, but possess an oxygenated 4β-substituent as a substitute for the oxetane ring oxygen atom. These derivatives provide additional information about the importance of this oxygen atom for cytotoxic activity.

Semisynthesis of D-ring-modified taxoids: Thietane derivatives from taxine B

The semisynthesis of 7-deoxobaccatin III derivatives, in which the oxygen atom in ring D is substituted for a sulfur atom, is presented; the starting material is the natural taxine B and isotaxine B extracted from the needles of Taxus baccata. (C) 2000 Elsevier Science Ltd.

Taxoids: 7-Deoxy-10-acetyldocetaxel and new analogs prepared from the yew tree alkaloids

Three new 7-deoxydocetaxel derivatives have been prepared from natural taxine B and isotaxine B: the first one, 2-debenzoyl-9-dihydro-1,2-O-benzylidine-9,10-O-isopropylidene-7-deoxydocetaxel has a slight cytotoxicity and a weak microtubule disassembly inhibitory activity; the other two derivatives, 9-dihydro-9,10-O-isopropylidene-7-deoxydocetaxel and 7-deoxy-10-acetyldocetaxel are cytotoxic and reveal a good microtubule disassembly inhibitory activity.