182075-12-3Relevant academic research and scientific papers
Stereoselective synthesis of antifungal sulfoximines, novel triazoles I
Kawanishi, Hiroyuki,Morimoto, Hiroshi,Nakano, Takao,Miyajima, Tadatoshi,Oda, Kuniyuki,Takeda, Katsuo,Yano, Shigeru,Hirano, Naomitsu,Tsujihara, Kenji
, p. 169 - 180 (2007/10/03)
Different types of sulfoximines, novel triazoles with three contiguous asymmetric centers on sulfur and two carbons, were stereoselectively synthesized and evaluated for antifungal activity. (R)-S-2-[(2R,3R)-3-(2,4- Difluorophenyl)-3-hydroxy-4-(1H-1,2,4-t
Stereoselective synthesis of antifungal sulfoximines, novel triazoles II
Kawanishi, Hiroyuki,Morimoto, Hiroshi,Nakano, Takao,Watanabe, Tatsuya,Oda, Kuniyuki,Tsujihara, Kenji
, p. 181 - 189 (2007/10/03)
Novel triazole derivatives with N-substituted sulfoximine moiety were synthesized and evaluated for antifungal activity. These compounds showed only significantly weak activity and the N-H sulfoximine moiety was extremely important for the activity. A more practical and effective stereoselective synthesis of N-H sulfoximine, (R)-S-2-[(2R,3R)-3-(2,4-difluorophenyl)-3- hydoroxy-4-(1H-1,2,4-triazol-1-yl)]butyl-S-methylsulfoximine (1), which was considered to be the most promising compound, has been developed.
