182173-65-5Relevant academic research and scientific papers
Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates
Araujo, Nuna C.P.,Barton, Victoria,Jones, Michael,Stocks, Paul A.,Ward, Stephen A.,Davies, Jill,Bray, Patrick G.,Shone, Alison E.,Cristiano, Maria L.S.,O'Neill, Paul M.
scheme or table, p. 2038 - 2043 (2009/11/30)
A novel series of semi-synthetic trioxaquines and synthetic trioxolaquines were prepared, in moderate to good yields. Antimalarial activity was evaluated against both the chloroquine-sensitive 3D7 and resistant K1 strain of Plasmodium falciparum and both
Mechanism-based design of parasite-targeted artemisinin derivatives: Synthesis and antimalarial activity of new diamine containing analogues
Hindley, Stephen,Ward, Stephen A.,Storr, Richard C.,Searle, Natalie L.,Bray, Patrick G.,Park, B. Kevin,Davies, Jill,O'Neill, Paul M.
, p. 1052 - 1063 (2007/10/03)
The potent antimalarial activity of chloroquine against chloroquine-sensitive strains can be attributed, in part, to its high accumulation in the acidic environment of the heme-rich parasite food vacuole. A key component of this intraparasitic chloroquine
