182193-03-9Relevant academic research and scientific papers
Oxazolidinones as alpha 1A receptor antagonists
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, (2008/06/13)
This invention is directed to oxazolidinone compounds which are selective antagonists for human alpha 1A receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia and for the treatment of any disease where the antagonism of the alpha 1A receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.
Synthetic applications of fluorinated phenyllithiums: Preparation of fluorinated α-methylstyrenes, benzhydrols, benzophenones and aryltrimethylsilanes
Yarwood, Thomas David,Waring, Anthony John,Coe, Paul Leslie
, p. 113 - 119 (2007/10/03)
Regioselective preparations of a number of fluorinated phenyllithiums have recently been reported, which in some cases also contain one or more bromine substituents. These have now been applied to the synthesis of the corresponding halogenated 2-arylpropenes (α-methyl-styrenes), benzhydrols, trifluoromethylbenzhydrols, benzophenones and aryltrimethylsilanes.
