272775-66-3

Upstream product

• 218292-27-4 3-(3,4-Difluoro-phenyl)-but-3-enoic acid methyl ester 
• 50-00-0 formaldehyd 
• 182193-03-9 1,2-difluoro-4-isopropenyl-benzene 
• 348-61-8 1-bromo-3,4-difluorobenzene 

Downstream Products

• 218292-40-1 (R)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(3,4-difluoro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester 
• 218292-34-3 (R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(3,4-difluoro-phenyl)-butane-1,2-diol 
• 218292-31-0 tert-Butyl-[3-(3,4-difluoro-phenyl)-but-3-enyloxy]-dimethyl-silane 

Relevant academic research and scientific papers

Practical carbonyl-ene reactions of α-methylstyrenes with paraformaldehyde promoted by a combined system of boron trifluoride and molecular sieves 4A

Matrix presented A combined system of boron trifluoride and molecular sieves is an efficient promoter for the carbonyl-ene reaction of a-methylsyrenes with paraformaldehyde. The coexistence of BF3-OEt2 and molecular sieves 4A is esse

An efficient synthesis of enantiomerically pure 2-[(2R)-arylmorpholin- 2-yl]ethanols, key intermediates of tachykinin receptor antagonist

We report herein an efficient and practical synthetic method for the preparation of enantiomerically pure 2[(2R)-arylmorpholin-2-yl]ethanols 1a- d, key intermediates of tachykinin receptor antagonist. Sharpless catalytic asymmetric dihydroxylation of 4a-d was employed to introduce the required absolute stereochemistry, and cyclization of 7a-d was accomplished by the Mitsunobu reaction.