182205-45-4Relevant academic research and scientific papers
Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities
Maiti, Arup,Reddy, P. V. Narasimha,Sturdy, Megan,Marler, Laura,Pegan, Scott D.,Mesecar, Andrew D.,Pezzuto, John M.,Cushman, Mark
experimental part, p. 1873 - 1884 (2009/12/31)
An efficient method has been developed to synthesize casimiroin (1), a component of the edible fruit of Casimiroa edulis, on a multigram scale in good overall yield. The route was versatile enough to provide an array of compound 1 analogues that were evaluated as QR2 and aromatase inhibitors. In addition, X-ray crystallography studies of QR2 in complex with compound 1 and one of its more potent analogues has provided insight into the mechanism of action of this new series of QR2 inhibitors. The initial biological investigations suggest that compound 1 and its analogues merit further investigation as potential chemopreventive or chemotherapeutic agents.
SRS-A Antagonist pyranoquinolone alkaloids from East African Fagara plants and their synthesis
Kamikawa, Tadao,Hanaoka, Yasuyuki,Fujie, Satoru,Saito, Ken,Yamagiwa, Yoshiro,Fukuhara, Katsuya,Kubo, Isao
, p. 1317 - 1320 (2007/10/03)
Three pyranoquinolone alkaloids isolated from two East African Fagara plants have been found to exhibit SRS-A antagonist action. Their synthesis has been accomplished, using a modified Coppola's method or a thermal cyclization followed by an electrocyclic
