182219-57-4

Upstream product

• 29736-80-9 3,5-dioxohexanoic acid methyl ester 
• 1517-82-4 (1R,2S,5R,SS)-(-)-menthyl p-toluenesulfinate 

Downstream Products

• 256659-01-5 (+)-(2S,4S)-1-acetoxy-6-benzyloxy-syn-2,4-(isopropylidenedioxy)-1-(p-tolylthio)hexane 
• 256659-00-4 (+)-[2S,4S,S(R)]-6-benzyloxy-syn-2,4-(isopropylidenedioxy)-1-(p-tolylsulfinyl)hexane 
• 256658-99-8 (+)-[2S,4S,R(S)]-6-hydroxy-syn-2,4-(isopropylidenedioxy)-1-(p-tolylsulfinyl)hexane 
• 171523-69-6 (+)-<3(R),5(S),S(R)>-Methyl syn-3,5-(isopropylidenedioxy)-6-(p-tolylsulfinyl)hexanoate 
• 263369-09-1 3'-methyl-2'-butenyl (+)-(5S,7R,13R,2E,10E)-13-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)-7-methyl-9-oxo-8-oxatetradeca-2,10-dienoate 
• 263369-10-4 (+)-(5S,7R,13R,2E,10E)-5-(tert-butyldiphenylsilyloxy)-13-hydroxy-7-methyl-9-oxo-8-oxatetradeca-2,10-dienoic acid 
• 263369-08-0 3'-methyl-2'-butenyl (+)-(5S,7R,2E)-5-(tert-butyldiphenylsilyloxy)-7-hydroxyoctenoate 
• 263369-07-9 methyl (+)-(5S,7R,2E)-5-(tert-butyldiphenylsilyloxy)-7-hydroxyoctenoate 
• 263369-05-7 (+)-(3R,5R)-3-(tert-butyldiphenylsilyloxy)-5-hexanolide 
• 263369-06-8 (4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-tetrahydro-pyran-2-ol 
• 171523-68-5 (+)-<3(R),5(S),S(R)> methyl 3,5-dihydroxy-6-(p-tolylsulfinyl) hexanoate 
• 50376-40-4 (-)-colletol 
• 171523-67-4 (+)-<5(S),S(R)> methyl 3-oxo-5-hydroxy-6-(p-tolylsulfinyl) hexanoate 

Relevant academic research and scientific papers

A chiral β,δ-dioxo-ε-sulfinyl ester in a convergent enantioselective synthesis towards the C1-C13 polyol fragment of amphotericin B

This paper describes an efficient stereocontrolled and convergent approach towards the C1-C13 polyol fragment of amphotericin B. The strategy is based on the stereoselective reduction of a chiral β,γ-dioxo- ε-sulfinyl ester to obtain anti-or syn-1,3-diols.

Enantioselective synthesis of the unsymmetrical bis(lactone) (-)- (3E,6R,9E,12S,14R)-colletol induced by chiral sulfoxides and an approach to (+)-colletodiol by asymmetric hydroxylation of an α,β-hydroxy lactone

A general synthetic strategy towards the two bis(lactones) (-)colletol (1) and (+)-colletodiol (2) is described. A common intermediate in this synthesis is the 6-membered hydroxy lactone (+)-(3R,5R)-3-hydroxy-5- hexanolide (6), readily prepared by stereos