182244-33-3

Usage

Uses

Used in Bioconjugation:
Bromoacetamido-PEG2-Boc-amine is used as a bioconjugation agent for the attachment of biomolecules to other molecules or surfaces. The bromide group facilitates nucleophilic substitution, allowing for the covalent linking of target biomolecules, while the PEG spacer improves solubility and stability.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Bromoacetamido-PEG2-Boc-amine is used as a component in drug delivery systems. The PEG spacer and Boc-protected amine provide opportunities for the attachment of drug molecules, enhancing their solubility, bioavailability, and therapeutic efficacy.
Used in Diagnostic Imaging:
Bromoacetamido-PEG2-Boc-amine is utilized as a contrast agent in diagnostic imaging. The PEG spacer and Boc-protected amine can be functionalized to bind with imaging agents, improving their solubility and circulation time in the body, leading to enhanced imaging capabilities.
Used in Chemical Synthesis:
In the field of chemical synthesis, Bromoacetamido-PEG2-Boc-amine serves as an intermediate or building block for the synthesis of complex molecules. The bromide group allows for nucleophilic substitution with various nucleophiles, enabling the creation of a wide range of PEGylated compounds with diverse applications.

Upstream product

• 598-21-0 2-Bromoacetyl bromide 
• 153086-78-3 tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate 
• 79-08-3 bromoacetic acid 
• 13094-51-4 bromoacetic anhydride 

Downstream Products

• 1256258-89-5 methyl 4-(2,2-dimethyl-4,15-dioxo-3,8,11-trioxa-5,14-diazahexadecan-16-yloxy)benzoate 

Relevant academic research and scientific papers

CHROMOGENIC PEROXIDASE SUBSTRATES

Chromogenic conjugates for color-based detection of targets are described. The conjugates comprise a chromogenic moiety such as rhodamine, rhodol or fluorescein. The chromogenic moiety is linked to a peroxidase substrate. The chromogenic conjugates can be used in immunohistochemical analysis and in situ hybridization. The conjugates can be used to detect 1, 2, 3 or more targets in a sample by color.

METHODS FOR MAKING CONJUGATES FROM DISULFIDE-CONTAINING PROTEINS

The invention provides methods to prepare protein conjugates from proteins having at least two cysteines. In one embodiment, a protein with a disulfide linkage is reduced to provide two free cysteines for reaction with a 1,3-dihaloacetone or similar reactant, linking the sulfur atoms of the two cysteines together. The ketone inserted between the sulfur atoms is then used to form a Schiff base to an aminated payload molecule, thus conjugating the protein to a payload. In another embodiment, two cysteine residues are tied together by reaction with a 1,3-dihaloacetone or similar reactant. The linkage between the sulfur atoms in each case holds the protein or peptide in a constrained conformation, while also providing a convenient place for attaching a payload with good specificity and efficiency.

Plasma-mediated release of morphine from synthesized prodrugs

Two morphine prodrugs ('PDA' and 'PDB') were synthesized and the kinetics of esterase-mediated morphine release from these prodrugs were determined when incubated with plasma from different animal species. Morphine was rapidly released from PDA by all spe

A new multi-charged C60 derivative: Synthesis and biological properties

A new water-soluble multi-charged monoadduct fullero[60]pyrrolidine derivative with three ethylene glycol chains and three ammonium groups has been synthesized by means of two alternative synthetic pathways. Increasing the concentration of this C60 derivative did not show a significant modification of concentration of superoxide anion radical O2-, generated by the xanthine/xanthine oxidase system. Moreover, this C60 derivative was ineffective for neuroprotection in quantitative assessment of a neuronal injury considered to occur via radicals. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.