1256258-89-5Relevant academic research and scientific papers
BENZODICYCLOALKANE DERIVATIVE, PREPARATION METHOD AND USE THEREOF
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, (2019/06/19)
It is provided herein a benzobicycloalkane derivative, and a preparation method and use thereof. In particular, it is provided herein a compound of Formula (I), or a pharmaceutically acceptable salt, stereoisomer or solvate thereof, a preparation method, and a use thereof in preparation of drugs for treating pain.
Plasma-mediated release of morphine from synthesized prodrugs
Thomas, Thommey P.,Huang, Baohua,Desai, Ankur,Zong, Hong,Cheng, Xue-Min,Kotlyar, Alina,Leroueil, Pascale R.,Dunham, Thomas,Van Der Spek, Abraham,Ward, Brent B.,Baker Jr., James R.
supporting information; experimental part, p. 6250 - 6253 (2010/12/18)
Two morphine prodrugs ('PDA' and 'PDB') were synthesized and the kinetics of esterase-mediated morphine release from these prodrugs were determined when incubated with plasma from different animal species. Morphine was rapidly released from PDA by all spe
