18226-43-2

Upstream product

• 927-74-2 3-Butyn-1-ol 
• 18226-42-1 1,3,5-Tris(bromomethyl)benzene 
• 80935-59-7 2,2',2''-(benzene-1,3,5-triyl)triacetonitrile 
• 860518-55-4 C₁₂H₁₂O₃ 
• 4435-67-0 1,3,5-benzenetriacetic acid 
• 859032-83-0 benzene-1,3,5-triyl-tri-acetic acid triethyl ester 

Downstream Products

• 18226-49-8 TAB₀₀₂ 
• 18226-48-7 1.3.5-Tris-(β-cyanethyl)-benzol 
• 41009-91-0 1,3,5-tris(3-hydroxypropyl)benzene 
• 218146-28-2 1,3,5-Tris-(2-but-3-ynyloxy-ethyl)-benzene 
• 218146-27-1 1,3,5-Tris-[2-(2-bromo-ethoxy)-ethyl]-benzene 
• 218146-26-0 2-(2-{3,5-Bis-[2-(2-hydroxy-ethoxy)-ethyl]-phenyl}-ethoxy)-ethanol 
• 218146-25-9 1,3,5-tris[2-[2-(tetrahydropyran-2-yloxy)ethoxy]ethyl]benzene 
• 213555-16-9 1,3,5-tris[(2'-tosyloxy)ethyl]benzene 
• 18226-47-6 1,3,5-tris(2'-bromoethyl)benzene 
• 18226-46-5 1,3,5-tris(2-chloroethyl)benzene 
• 213555-23-8 C₄₈H₅₇N₃O₉S₃ 

Relevant academic research and scientific papers

Antibiotic Conjugates with an Artificial MECAM-Based Siderophore Are Potent Agents against Gram-Positive and Gram-Negative Bacterial Pathogens

The development of novel drugs against Gram-negative bacteria represents an urgent medical need. To overcome their outer cell membrane, we synthesized conjugates of antibiotics and artificial siderophores based on the MECAM core, which are imported by bacterial iron uptake systems. Structures, spin states, and iron binding properties were predicted in silico using density functional theory. The capability of MECAM to function as an effective artificial siderophore in Escherichia coli was proven in microbiological growth recovery and bioanalytical assays. Following a linker optimization focused on transport efficiency, five β-lactam and one daptomycin conjugates were prepared. The most potent conjugate 27 showed growth inhibition of Gram-positive and Gram-negative multidrug-resistant pathogens at nanomolar concentrations. The uptake pathway of MECAMs was deciphered by knockout mutants and highlighted the relevance of FepA, CirA, and Fiu. Resistance against 27 was mediated by a mutation in the gene encoding ExbB, which is involved in siderophore transport.

Synthesis of new cores and their use in the preparation of polyester dendrimers

Six dendrimer and dendron cores terminated by hydroxyl groups that are neither phenolic nor cleavable by hydrogenolysis have been prepared in a consistent one-pot manner from terminal allyl groups by reduction of the product of reductive ozonolysis. Some of the terminal allyl derivatives are new and others have been prepared by new methods. The well-known O-benzylidene derivative of 2,2′-bis(hydroxymethyl)propanoic acid was shown to be the cis-stereoisomer. A new AB3-type anhydride, tris(benzyloxymethyl) acetic anhydride has been prepared. It was demonstrated that these cores and dendrons could be assembled into first and second generation homo- and mixed polyester dendrimers.

Facile Synthesis of Benzene-bridged Azaoxamacrobicyclic Ligands

Five new barrel-shaped macrobicyclic compounds capable of complexation with anions have been prepared. Intermediate triamines were prepared in one-step using a triple Mitsonobu reaction, thereby shortening the overall synthetic sequence. A previously prepared benzene-bridged hexaazamacrocycle was prepared in only four-steps.