4435-67-0

Usage

Uses

Used in Chemical Industries:
1 3 5-BenzeneTriacetic Acid is used as an intermediate in synthesis for various chemical processes. Its unique acidic properties and triprotic nature make it a valuable component in the production of different chemical compounds.
Used in Research and Development:
1 3 5-BenzeneTriacetic Acid is used as a research compound for studying its chemical properties and potential applications in various fields. Its structure and reactivity can provide insights into the development of new synthetic pathways and chemical reactions.

Upstream product

• 779-90-8 1,3,5-triacetylbenzene 
• 17299-97-7 α,α',α''-trichloromesitylene 
• 7567-63-7 1,3,5-Triethynylbenzene 
• 18226-42-1 1,3,5-Tris(bromomethyl)benzene 

Downstream Products

• 859032-83-0 benzene-1,3,5-triyl-tri-acetic acid triethyl ester 
• 110059-69-3 benzene-1,3,5-triyl-tri-acetic acid tris-(2-bromo-ethyl ester) 
• 77354-22-4 1,3,5-benzene-triacetyl chloride 
• 85294-18-4 1,3,5-tris(carboxymethyl-α,α-d2)benzene 
• 204263-36-5 2-(3,5-Bis-but-3-ynylcarbamoylmethyl-phenyl)-N-but-3-ynyl-acetamide 
• 18226-43-2 1,3,5-benzenetriethanol 
• 18226-47-6 1,3,5-tris(2'-bromoethyl)benzene 
• 80935-59-7 2,2',2''-(benzene-1,3,5-triyl)triacetonitrile 

Relevant academic research and scientific papers

Antibiotic Conjugates with an Artificial MECAM-Based Siderophore Are Potent Agents against Gram-Positive and Gram-Negative Bacterial Pathogens

The development of novel drugs against Gram-negative bacteria represents an urgent medical need. To overcome their outer cell membrane, we synthesized conjugates of antibiotics and artificial siderophores based on the MECAM core, which are imported by bacterial iron uptake systems. Structures, spin states, and iron binding properties were predicted in silico using density functional theory. The capability of MECAM to function as an effective artificial siderophore in Escherichia coli was proven in microbiological growth recovery and bioanalytical assays. Following a linker optimization focused on transport efficiency, five β-lactam and one daptomycin conjugates were prepared. The most potent conjugate 27 showed growth inhibition of Gram-positive and Gram-negative multidrug-resistant pathogens at nanomolar concentrations. The uptake pathway of MECAMs was deciphered by knockout mutants and highlighted the relevance of FepA, CirA, and Fiu. Resistance against 27 was mediated by a mutation in the gene encoding ExbB, which is involved in siderophore transport.

Oxidation of Alkynyl Boronates to Carboxylic Acids, Esters, and Amides

A general efficient protocol was developed for the synthesis of carboxylic acids, esters, and amides through oxidation of alkynyl boronates, generated directly from terminal alkynes. This protocol represents the first example of C(sp)?B bond oxidation. This approach displays a broad substrate scope, including aryl and alkyl alkynes, and exhibits excellent functional group tolerance. Water, primary and secondary alcohols, and amines are suitable nucleophiles for this transformation. Notably, amino acids and peptides can be used as nucleophiles, providing an efficient method for the synthesis and modification of peptides. The practicability of this methodology was further highlighted by the preparation of pharmaceutical molecules.

Preparation method of acid with different substituent groups

The invention discloses a preparation method of an acid with different substituent groups. A terminal alkyne is lithiated with n-butyllithium, and then reacts with isopropoxyboronic acid pinacol ester, hydrogen chloride is added to achieve quenching, then the obtained reaction product is oxidized by an oxidizing agent, and the oxidized reaction product is separated and purified to obtain the acid.The method of the invention has the advantages of simplicity in operation, one-pot process preparation, no metal catalysis, nontoxic reagents, greenness, environmental friendliness and high atomic utilization rate, and provides a novel and quick way for preparing the acid with different substituent groups; and the obtained acid is an important fine chemical product, and can be widely used in fields of medicines, pesticides, spices and other industries.

Synthesis of Macrocyclic (1,3,5)Cyclophane Polylactones

A series of new macrocyclic cyclophane polylactones has been synthesized by one-step condensation of the appropriate tri(acid chloride)s and triols using the silver cyanide-promoted esterification procedure.