18226-50-1Relevant articles and documents
Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:Diacylglycerol acyltransferase 1
Yeh, Vince S. C.,Beno, David W. A.,Brodjian, Sevan,Brune, Michael E.,Cullen, Steven C.,Dayton, Brian D.,Dhaon, Madhup K.,Falls, Hugh D.,Gao, Ju,Grihalde, Nelson,Hajduk, Philip,Hansen, T. Matthew,Judd, Andrew S.,King, Andrew J.,Klix, Russel C.,Larson, Kelly J.,Lau, Yau Y.,Marsh, Kennan C.,Mittelstadt, Scott W.,Plata, Dan,Rozema, Michael J.,Segreti, Jason A.,Stoner, Eric J.,Voorbach, Martin J.,Wang, Xiaojun,Xin, Xili,Zhao, Gang,Collins, Christine A.,Cox, Bryan F.,Reilly, Regina M.,Kym, Philip R.,Souers, Andrew J.
supporting information; experimental part, p. 1751 - 1757 (2012/05/04)
A high-throughput screen against human DGAT-1 led to the identification of a core structure that was subsequently optimized to afford the potent, selective, and orally bioavailable compound 14. Oral administration at doses ≥0.03 mg/kg significantly reduced postprandial triglycerides in mice following an oral lipid challenge. Further assessment in both acute and chronic safety pharmacology and toxicology studies demonstrated a clean profile up to high plasma levels, thus culminating in the nomination of 14 as clinical candidate ABT-046.
TRANSAMINATION OF TERTIARY ENAMINES, SYNTHESIS OF β-SUBSTITUTED N-BENZYLENAMINES
Granik, V. G.,Zhidkova, A. M.,Zhivotovskaya, I. S.,Solov'eva, N. P.,Polievktov, M. K.
, p. 2163 - 2166 (2007/10/02)
The rate constants for the transamination of tertiary enamines by means of benzylamine were measured by polarography.The PMR spectra of the obtained compounds indicate the presence of strong intramolecular hydrogen bonds, due to the presence of the NH gro
Herbicidal use of β-aminoatroponitriles
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, (2008/06/13)
A class of β-aminoatroponitriles are useful herbicides. The compounds have a meta-substituent, or no substituent, on the phenyl ring, and the amino group may be substituted with lower alkyl groups.
