182287-63-4 Usage
Description
4-(Bromomethyl)-3-iodobenzonitrile, with the molecular formula C8H5BrIN, is a white to light yellow solid chemical compound. It is primarily recognized for its role as an intermediate in the synthesis of pharmaceuticals and agrochemicals, contributing to the development of various functionalized aromatic compounds in organic synthesis.
Uses
Used in Pharmaceutical Industry:
4-(Bromomethyl)-3-iodobenzonitrile is used as a synthetic intermediate for the production of pharmaceuticals, facilitating the creation of a range of medicinal compounds that address diverse health conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(Bromomethyl)-3-iodobenzonitrile serves as a key intermediate, playing a crucial role in the synthesis of various agrochemicals that are essential for crop protection and enhancement of agricultural productivity.
Used in Organic Synthesis:
4-(Bromomethyl)-3-iodobenzonitrile is utilized as a precursor in organic synthesis for preparing a variety of functionalized aromatic compounds, which are vital in the development of new materials and chemical entities with specific applications.
Safety and Environmental Considerations:
It is imperative to handle 4-(Bromomethyl)-3-iodobenzonitrile with care due to its classification as a hazardous substance. Exposure may result in skin and eye irritation, as well as respiratory issues if inhaled. Moreover, proper handling and disposal are necessary to prevent harm to aquatic life and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 182287-63-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,2,2,8 and 7 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 182287-63:
(8*1)+(7*8)+(6*2)+(5*2)+(4*8)+(3*7)+(2*6)+(1*3)=154
154 % 10 = 4
So 182287-63-4 is a valid CAS Registry Number.
182287-63-4Relevant articles and documents
ALDOSTERONE SYNTHASE INHIBITOR
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Paragraph 0016; 0076; 0077, (2018/10/10)
PROBLEM TO BE SOLVED: To provide a compound having aldosterone synthase inhibition effect useful for treatment of primary aldosteronism causing hypertension or hypokalemia by overproduction of aldosterone, and a pharmaceuticals containing the compound. SOLUTION: There are provided an imidazole compound including 4-[5-(2-fluoroethyl)-1H-imidazole-1-ylmethyl]-3-iodobenzonitrile, 1-(3-bromo-4-cyanobenzyl)-1H-imidazole-5-carboxylic acid methyl, 1-(2-iodo-4-nitrobenzyl)-1H-imidazole-5-carboxylic acid methyl, 1-(3,5-di-tert-butylphenyl)-1H-imidazole-5-carboxylic acid methyl, 1-(2H-chromene-2-on-6-ylmethyl)-1H-imidazole-5-carboxylic acid methyl and 1-(2H-chromene-2-on-6-ylmethyl)-5-iodo-1H-imidazole as examples, and pharmaceuticals containing the compound. COPYRIGHT: (C)2015,JPOandINPIT
Synthesis and biological evaluation of 4-[(3-methyl-3H-imidazol-4-yl)-(2-phenylethynyl-benzyloxy)-methyl]-benzonitrile as novel farnesyltransferase inhibitor
Lin, Nan-Horng,Wang, Le,Cohen, Jerry,Gu, Wen-Zhen,Frost, David,Zhang, Haiying,Rosenberg, Saul,Sham, Hing
, p. 3821 - 3825 (2007/10/03)
Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anticancer agents. Analogues of the potent FTI, 4-[3-biphenyl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl] -1-yl-benzonitrile, were synthesized and tested in vitro for their in
