1823-00-3

Basic information

• Product Name: 1,2,4-Oxadiazole, 3-(phenylmethyl)-5-(trichloromethyl)-
• CAS NO: 1823-00-3
• Molecular Formula: C10H7Cl3N2O
• Molecular Weight: 277.537
• Mol File: 1823-00-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,2,4-Oxadiazole, 3-(phenylmethyl)-5-(trichloromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Oxadiazole, 3-(phenylmethyl)-5-(trichloromethyl)-(1823-00-3)
• EPA Substance Registry System: 1,2,4-Oxadiazole, 3-(phenylmethyl)-5-(trichloromethyl)-(1823-00-3)

Safety Data

• Hazardous Substances Data: 1823-00-3(Hazardous Substances Data)

Usage

Chemical Family

Belongs to the oxadiazole family

Molecular Weight

188.53 g/mol

Applications

a. Intermediate in the synthesis of pharmaceuticals and agrochemicals

Potential biological activities

antimicrobial and anti-cancer properties
c. Investigated for use as a photoinitiator in polymer chemistry

Versatility

Various potential applications in medicine, agriculture, and materials science

Upstream product

• 19227-11-3 N'-hydroxy-2-phenylethanimidamide 
• 4124-31-6 trichloroacetic acid anhydride 
• 76-02-8 trifluoroacetyl chloride 
• 140-29-4 phenylacetonitrile 
• 1008451-58-8 4-chloro-2-methoxynicotinic aldehyde 

Downstream Products

• 55654-03-0 3-benzyl[1.2.4]oxadiazol-5-ylamine 

Relevant articles and documents

Synthesis and multiparametric evaluation of thiadiazoles and oxadiazoles as diacylglycerol acyltransferase type 1 inhibitors

Chemical modulation of a formerly disclosed DGAT-1 inhibitor resulted in the identification of a compound with a suitable profile for preclinical development. Optimisation of solubility is discussed and a PK/PD study is presented.

DERIVATIVES OF OXADIAZOLE AND PYRIDAZINE, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS

The invention relates to compounds of formula (I): in which: n is equal to 0 or 1; D represents an oxygen atom or a bond; W represents a nitrogen atom or a —CH— group; X1 represents a nitrogen atom or a —CH═CH— group; X2 represents an oxygen atom or a nitrogen atom; X3 represents an oxygen atom or a nitrogen atom; one of X1, X2, X3 being other than a nitrogen atom, X2 and X3 not being an oxygen atom at the same time; R1, R2 are absent or represent, (i) independently of one another, a hydrogen atom or a (C1-C4)alkyl group, (ii) R1 and R2 may form, with the carbon atom to which they are attached, a —(C3-C10)cycloalkyl- group; Y represents a —(C3-C10)cycloalkyl-, aryl or aryloxy group, said groups being optionally substituted with one or more substituents chosen from a halogen atom or a (C1-C6)alkoxy group; Z1 is absent or represents an —NH— function; Z2 and Z3 are as defined in the description. The invention also relates to a process for preparing compounds of formula (I), compositions containing them and their application in therapeutics.