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Usage

Uses

Used in Pharmaceutical Industry:
5-bromo-1-phenyl-1H-tetrazole is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to enhance the reactivity and functionalization of organic compounds, contributing to the development of new drugs with improved properties.
Used in Agrochemical Industry:
5-bromo-1-phenyl-1H-tetrazole is used as a reagent in the synthesis of agrochemicals to improve the effectiveness and selectivity of these compounds, leading to more efficient and environmentally friendly products.
Used in Organic Chemistry Research:
5-bromo-1-phenyl-1H-tetrazole is used as a versatile building block in organic chemistry research for its high reactivity and potential to undergo various chemical transformations, enabling the exploration of new synthetic pathways and the development of novel organic compounds.

Upstream product

• 5378-52-9 phenyl-1H-tetrazole 
• 5467-78-7 fenamole 
• 1197040-29-1 phenyl isocyanate 
• 86-93-1 1-Phenyl-1H-tetrazole-5-thiol 
• 5097-82-5 5-hydroxy-1-phenyltetrazole 

Downstream Products

• 5097-82-5 5-phenyl-1H-tetrazolone 
• 5533-43-7 5-hydrazinyl-1-phenyl-1H-tetrazole 
• 5378-52-9 phenyl-1H-tetrazole 
• 14210-35-6 5-azido-1-phenyl-1H-tetrazole 
• 86-93-1 1-Phenyl-1H-tetrazole-5-thiol 

Relevant academic research and scientific papers

Recycling method of 1-phenyl-5-hydroxytetrazole

The invention discloses a recycling method of 1-phenyl-5-hydroxytetrazole, and belongs to the technical field of medicinal chemistry. The preparation method comprises the following steps: a byproduct1-phenyl-5-hydroxytetrazole generated in preparation process of a rosuvastatin calcium intermediate is converted into 1-phenyl-5-mercaptotetrazole; and meanwhile, the 1-phenyl-5-mercaptotetrazole is further used for preparing a rosuvastatin calcium intermediate or rosuvastatin calcium. According to the method disclosed by the invention, reasonable recycling of the byproduct 1-phenyl-5-hydroxytetrazole is realized, the raw materials are fully utilized, the production cost of rosuvastatin calcium and the intermediate thereof is reduced, and the emission of three wastes is reduced.

An efficient synthesis of 1-substituted 5-bromo-1 H -tetrazoles

1-Substituted 1H-tetrazole-5-thiols were efficiently converted into the corresponding 1-substituted 5-bromo-1H-tetrazoles by treatment with zinc(II) bromide and 50% hydrogen peroxide or 36% peracetic acid at 70-80 °C. In most cases, the 5-bromotetrazole p