182346-08-3Relevant academic research and scientific papers
Synthese des 5-desoxy-5.5.5-trifluoro-D- et -L-pentofuranoses
Munier, Pascal,Giudicelli, Marie-Beatrice,Picq, Dominique,Anker, Daniel
, p. 739 - 762 (2007/10/03)
Synthetic pathways leading to 5-deoxy-5,5,5-trifluoropentofuranoses are reported. The main difficulty was to obtain a good diastereoselectivity at the C-4 carbon bearing the CF3 group. For the ribose and the lyxose derivatives the problem was p
Trifluoromethylation of Sugar 1,4-Lactones: Synthesis of 5-Deoxy-5,5,5-Trifluoro-D and L-Ribose and Lyxose Derivatives
Munier, Pascal,Picq, Dominique,Anker, Daniel
, p. 8241 - 8244 (2007/10/02)
The four 5-deoxy-5,5,5-trifluoro-D and L-ribo and -lyxo furanoses were synthesized from lactones using CF3SiMe3 in 5 or 6 steps and 30-40percent overall yield.The key step was a stereoselective reduction of 1,1,1-trifluoro-2-ketoses with LiAlH4 or NaBH4 a
