182355-48-2Relevant academic research and scientific papers
A new approach to the synthesis of 4,5-dioxoaporphine alkaloids from preformed biaryl bond precursors
Suau, Rafael,Lopez-Romero, Juan Manuel,Rico, Rodrigo,Alonso, Francisco J.,Lobo, Carolina
, p. 11307 - 11320 (1996)
The synthesis of cepharadione-B and 2-demethoxy analogues is described. Starting from fluorenones, ring C was formed by cyclization of (biphenyl-2-yl)acetyl morpholines under Bischler-Napieralsky conditions. The photochemistry of chloroacetamides was used to form ring B. The cytotoxicity of these compounds on several tumor cell lines was evaluated.
