1823642-95-0

Basic information

• Product Name: 5-Bromo-4-(1,1-difluoro-ethyl)-pyrimidine
• Synonyms: 5-Bromo-4-(1,1-difluoro-ethyl)-pyrimidine
• CAS NO: 1823642-95-0
• Molecular Formula: C6H5BrF2N2
• Molecular Weight: 223.0181064
• Mol File: 1823642-95-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Bromo-4-(1,1-difluoro-ethyl)-pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-4-(1,1-difluoro-ethyl)-pyrimidine(1823642-95-0)
• EPA Substance Registry System: 5-Bromo-4-(1,1-difluoro-ethyl)-pyrimidine(1823642-95-0)

Safety Data

• Hazardous Substances Data: 1823642-95-0(Hazardous Substances Data)

Upstream product

• 141602-27-9 4-chloro-5-bromo-6-ethyl-pyrimidine 
• 124703-78-2 6-ethyl-4(3H)-pyrimidinone 

Relevant articles and documents

Drug intermediate and preparation method thereof

The invention provides a drug intermediate and a preparation method thereof. The method comprises a preparation method of a compound. The compound is [4-(1,1-difluoro-ethyl)-pyridine]-5-methylamine hydrochloride. The method comprises the following steps of using 4-(1,1-difluoro ethyl)-5-pyridine formaldehyde to take reduction reaction with sodium borohydride in water to obtain 4-(1,1-difluoro ethyl)-5-pyridine-methyl alcohol. A pyridine derivative M can be used for the development and screening of new medicine for treating various chronic diseases such as diabetes mellitus and alopecia. The synthesis method of the compound also has the advantages that the operation is simple; the efficiency is high; the raw material cost is low. The synthesis route has the advantages that the process is simple and convenient; the synthesis route is suitable for factory amplified production.