182370-58-7

Upstream product

• 245362-53-2 (2R)-N-[(1S)-phenylethyl]-2-hydroxymethyl aziridine 
• 68820-69-9 methyl (2R,1'S)-1-(1'-phenyl-ethyl)-aziridine-2-carboxylate 

Downstream Products

• 945676-54-0 diethyl (R)-hydroxy{(R)-1-[(S)-1-phenylethyl]aziridin-2-yl}methylphosphonate 
• 945676-53-9 diethyl (S)-hydroxy{(R)-1-[(S)-1-phenylethyl]aziridin-2-yl}methylphosphonate 
• 1438281-06-1 (2S,3R,4R,5R)-2-(2-hydroxyethyl)-5-(hydroxymethyl)-1-((S)-1-phenylethyl)pyrrolidine-3,4-diol 
• 1438281-05-0 ((3aS,5R,6S,6aR)-6-hydroxy-2-oxo-4-((S)-1-phenylethyl)hexahydro-2H-furo[3,2-b]pyrrol-5-yl)methyl acetate 
• 1438281-04-9 (2S,3R,4S,5R)-2-(2-hydroxyethyl)-5-(hydroxymethyl)-1-((S)-1-phenylethyl)pyrrolidine-3,4-diol 
• 1438281-03-8 ((3aS,5R,6S,6aR)-6-((4-nitrobenzoyl)oxy)-2-oxo-4-((S)-1-phenylethyl)hexahydro-2H-furo[3,2-b]pyrrol-5-yl)methyl 4-nitrobenzoate 
• 1438281-02-7 (3aS,5R,6S,6aR)-6-hydroxy-5-(hydroxymethyl)-4-((S)-1-phenylethyl)hexahydro-2H-furo[3,2-b]pyrrol-2-one 
• 1438281-01-6 (R)-5-((S)-hydroxy((R)-1-((S)-1-phenylethyl)aziridin-2-yl)methyl)-furan-2(5H)-one 
• 182370-59-8 (R)-phenyl-((R)-1-((S)-1-phenylethyl)aziridin-2-yl)methanol 
• 945676-59-5 diethyl (R)-acetoxy {(R)-1-[(S)-1-phenylethyl]aziridin-2-yl}methylphosphonate 
• 945676-58-4 diethyl (S)-acetoxy {(R)-1-[(S)-1-phenylethyl]aziridin-2-yl}methylphosphonate 

Relevant academic research and scientific papers

Synthesis of the four enantiomers of diethyl 1,2-di(N-Boc-amino)propylphosphonates

A simple and efficient synthetic strategy to all four enantiomerically pure diethyl 1,2-di(N-Boc-amino)propylphosphonates has been elaborated starting from the corresponding N-[(R)-(1-phenylethyl)]aziridine-(2S)- and N-[(S)-(1-phenylethyl)]aziridine-(2R)-

METHODS FOR TREATING COGNITIVE DISORDERS USING 1-ARYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES, 1-HETEROARYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES AND RELATED COMPOUNDS

Disclosed herein are methods of treating a patient suffering from a cognitive disorder using compounds of the following formula, Formula (2), wherein the variables have the meaning defined in the specification.

METHODS FOR TREATING COGNITIVE DISORDERS USING 1-BENZYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES, 3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS

Disclosed herein are methods of treating a patient suffering from a cognitive disorder using the following compounds (I, II, III, IV, V, VI, VII, VIII, IX, X, XI, XII, XIII).

METHODS FOR TREATING CHRONIC PAIN USING 1-BENZYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES,3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS

Disclosed herein are methods of treating a patient suffering from one or more types of chronic pain using the following compounds:

Synthesis of four enantiomers of 2-acetamido-1-hydroxypropylphosphonates

Enantiomerically pure diethyl 2-acetamido-1-hydroxypropylphosphonates were synthesised from N-[(R)-(1-phenylethyl)]aziridine-(2S)- and N-[(S)-(1-phenylethyl)]aziridine-(2R)-carboxaldehydes via phosphonylation followed by acetylation of the hydroxy groups

METHODS OF USING AS ANALGESICS 1-BENZYL-1-HYDROXY-2, 3-DIAMINO-PROPYL AMINES, 3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS

The compounds shown by the structural formulas below have analgesic effect and are used in compositions and methods for treating mammal in need of such treatment.