68820-69-9

Upstream product

• 1729-67-5 Methyl 2,3-dibromopropionate 
• 2627-86-3 (S)-1-phenyl-ethylamine 

Downstream Products

• 139952-72-0 methyl 5,6-dihydro-2-methoxy-4-(1S-phenylethyl)-imidazo<1,2-b><1,2,4>triazole-5R-carboxylate 
• 245362-53-2 (2R)-N-[(1S)-phenylethyl]-2-hydroxymethyl aziridine 
• 1315320-56-9 diphenyl-((R)-1-((S)-1-phenylethyl)aziridin-2-yl)-methanol 
• 139924-82-6 5,6-dihydro-2-methoxy-4-(1S-phenylethyl)-imidazo<1,2-b><1,2,4>triazole-5R-carboxylic acid 
• 945676-53-9 diethyl (S)-hydroxy{(R)-1-[(S)-1-phenylethyl]aziridin-2-yl}methylphosphonate 
• 182370-58-7 (R)-1-((S)-1-phenylethyl)aziridine-2-carbaldehyde 
• 945676-59-5 diethyl (R)-acetoxy {(R)-1-[(S)-1-phenylethyl]aziridin-2-yl}methylphosphonate 
• 945676-58-4 diethyl (S)-acetoxy {(R)-1-[(S)-1-phenylethyl]aziridin-2-yl}methylphosphonate 
• 945676-54-0 diethyl (R)-hydroxy{(R)-1-[(S)-1-phenylethyl]aziridin-2-yl}methylphosphonate 

Relevant academic research and scientific papers

Applications of conformational design: Rational resign of chiral ligands derived from a common chiral source for highly enantioselective preparations of (R)- and (S)-enantiomers of secondary alcohols

A pair of diastereomers 7 and 8 were easily synthesized in only two steps from a single common chiral source according to the concept of conformation design. The efficiency of these chiral ligands was evaluated by their application to the asymmetric addition of diethylzinc to aldehydes. This catalytic asymmetric process afforded the a most efficient access to the (R)- and (S)-enantiomers of a given secondary alcohol with similarly outstanding enantioselectivities and high yields. Our results also showed that the control of the desired conformer's population by conformation design is a new and practical strategy for the rational and precise design of highly enantioselective chiral ligands for metal-catalyzed reactions. The mechanism and possible transition states for the catalytic asymmetric addition have been proposed on the basis of previous studies as well as the crystal structure of the chiral ligands 7 and 8.

METHODS FOR TREATING COGNITIVE DISORDERS USING 1-BENZYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES, 3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS

Disclosed herein are methods of treating a patient suffering from a cognitive disorder using the following compounds (I, II, III, IV, V, VI, VII, VIII, IX, X, XI, XII, XIII).

METHODS FOR TREATING CHRONIC PAIN USING 1-BENZYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES,3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS

Disclosed herein are methods of treating a patient suffering from one or more types of chronic pain using the following compounds:

METHODS FOR TREATING COGNITIVE DISORDERS USING 1-ARYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES, 1-HETEROARYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES AND RELATED COMPOUNDS

Disclosed herein are methods of treating a patient suffering from a cognitive disorder using compounds of the following formula, Formula (2), wherein the variables have the meaning defined in the specification.

Expedient synthesis of substituted (S)-N-(α-methylbenzyl)aziridines

We report for the first time that after O-acylation the conjugate addition products of (S)-N-(α-methylbenzyl)hydroxylamine undergo an efficient diastereoselective 3-exo-tet ring-closure reaction affording 2- and 2,3-disubstituted-N-alkylaziridines in good