18239-47-9

Upstream product

• 3815-83-6 3,4-diphenylsydnone 
• 188724-74-5 4-benzoyl-1,5-diphenyl-1H-3-pyrazole carboxylic acid chloride 
• 71-43-2 benzene 
• 1262234-20-7 1,5-diphenyl-1H-pyrazole-3,4-dicarbonyl dichloride 

Downstream Products

• 110315-30-5 2,3,4,6-Tetraphenylthieno<3,4-c>pyrazol 
• 59349-08-5 2,3,4,7-Tetraphenylpyrazolo<3,4-d>pyridazin 

Relevant academic research and scientific papers

Synthesis and characterization of some pyrazole derivatives of 1,5-diphenyl-1H-pyrazole-3,4-dicarboxylic acid

(Chemical Equation Presented) Compound of 4-(ethoxycarbonyl)-1,5-diphenyl- 1H-pyrazole-3-carboxylic acid 2 was obtained from the reaction of ethyl 4,5-dioxo-2-phenyl-4,5-dihydrofuran-3-carboxylate and 1-benzylidene-2- phenylhydrazine. A number of substitute pyrazole dicarboxylic acid derivatives (4, 5a-c, 6, 7, 8, 9a-m, 10, 11, 12, 13, 14) were synthesized from 1,5-diphenyl-1H-pyrazole-3,4-dicarboxylic acid 3 which was prepared from basic hydrolysis of 2. Structures of synthesized compounds were characterized by 1H NMR, 13C NMR, Mass, FTIR, and elemental analysis.

Further derivatives of 4-benzoyl-1,5-diphenyl-1H-pyrazole-3-carboxylic acid and their antibacterial activities

Compound 4, 5, 6, 7, and 8 were synthesized from 4-benzoyl-1,5-diphenyl-1H- pyrazole-3-carboxylic acid 1 as a starting material. The pyrazolo[4,3-d] oxazinone 4 was obtained from direct reaction of the acid 1 with hydroxylamine hydrochloride. Acid chloride 2 was converted easily into the new derivatives consisting of 1-(4-benzoyl-1,5-diphenyl-1H-pyrazol-3-oyl)-sulfamide 5 and 3,4-dibenzoyl-1,5-diphenyl-1H-pyrazole 6. The nitrile derivative 7 was obtained by dehydration of the amide 3 in a mixture of SOCl2 and Dimethylformamide (DMF). Cyclocondensation reaction of 7 with anhydrous hydrazine led to the formation of 7-aminopyrazolo[3,4-d]pyridazine 8 derivative. These new synthesized compounds evaluated for their antibacterial activities against Gram-positive and Gram-negative bacteria using the tube dilution method. The finding of antibacterial activity study showed that the sulfamide derivative 5 was the best compound of the series, exhibiting antibacterial activity against both Gram-positive and Gram-negative bacteria.

Pyrrolo-1,3,4-thiadiazole Derivatives from Mesomeric Heteropentalenes and Azodicarboxylic Esters

The mesomeric heteropentalene betaines of type 4,7, and 18 display an unusual reaction behavior against the azodicarboxylic esters 8a-c.Surprisingly, 4 reacts with 8a,b to produce 17a,b, whereas the reaction of 4 with 8c leads to 11 and the novel azomethine imine 15.Also the reaction of 18 with 8a-c gives in two cases 20 or 25 beside the azomethine imine 19.Furthermore, 7 reacts with 8a to form 26, whereas the reaction of 7 with 8c surprisingly yields 29.Spectroscopic data as well as the results of the X-ray analyses of 17a and 19 are consistent with the structures.