188724-74-5Relevant articles and documents
Synthesis and characterization of new thiadiazole derivatives bearing a pyrazole moiety
Sa?mac?, Mustafa,Arslaner, ?iler,?ahin, Ertan
, p. 1134 - 1139 (2017/09/06)
A series of thidiazole derivatives (4, 7) from pyrazole-3-carboxylic acid chloride (2) and pyrazole-3,4- dicarboxylic acid chloride derivatives (6) were synthesized and characterized. The structures of the new compounds were confirmed byelemental analysis
Synthesis and reactions of 4-benzoyl-1,5-diaryl-1h-pyrazole-3-carbonyl chlorides with various semi- and thiosemicarbazides
Korkusuz, Elif,Yildirim, Ismail
experimental part, p. 472 - 476 (2010/06/19)
(Chemical Equation Presented) The 1H-pyrazole-3-carboxylic acids 2 were converted via reactions of their acid chlorides 3 with some semi- and thiosemicarbazide derivatives into the corresponding new phenylsemi- and thiosemicarbazides 4a-e, 6, 5-(pyrazol-3-yl)-4H-1,2,4-triazol-3-thiones 5a,b, and 2-(pyrazol-3-yl)-1,3,4-thiadiazol 7 derivatives, in good yields (45-97%, respectively). The reactions of 4a,c,e with Lawesson reagent lead to the products 6 and 7 formation. The structures of these newly synthesized compounds were determined. from the IR, 1H- and 13C-NMR spectroscopic data and elemental analyses.
Microwave-assisted studies on the reactions of the 4-Benzoyl-5-phenyl- 2,3-dihydro-2,3-furandione and derivatives
Akbas, Esvet,Sener, Ahmet
scheme or table, p. 103 - 105 (2010/08/05)
Varieties of heterocyclic compounds were prepared in good yield from 4-benzoyl-5-phenyl-2,3-dihydro-2,3- furandione under microwave irradiation conditions. The reaction revealed much shorter reaction times with comparable yields comparison to the corresponding thermal conditions.
Design, synthesis and biological investigation of certain pyrazole-3-carboxylic acid derivatives as novel carriers for nitric oxide
Abdel-Hafez, El-Shimaa M.N.,Abuo-Rahma, Gamal El-Din A.A.,Abdel-Aziz, Mohamed,Radwan, Mohamed F.,Farag, Hassan H.
body text, p. 3829 - 3837 (2009/10/02)
Some novel pyrazole-NO hybrid molecules 5a-e, 6, 8 and 10 were prepared through binding of the pyrazole-3-carboxylic acid derivatives with nitric oxide donor moiety like oxime or nitrate ester. The prepared compounds were evaluated for nitric oxide release, antibacterial and anti-inflammatory activities. The organic nitrate 10 exhibited the highest percentage of NO release using Griess diazotization method. Some of the prepared compounds exhibited remarkable antibacterial activity against Escherichia coli C-600, Pseudomonas aeruginosa, Bacillus subitilis and Staphylococcus aureus NCTC 6571 compared to ciprofloxacin. Most of the tested compounds showed significant anti-inflammatory activity compared to indomethacine using carrageenan induced paw edema method. In general, structural modification of compound 2 either to nitrate ester or oxime hybrids showed better anti-inflammatory with less ulcerogenic liability than their corresponding starting intermediates.
Functionalization and Cyclization Reactions of 4-Benzoyl-1,5-diphenyl- 1H-pyrazole-3-carboxylic Acid
Akcamur, Yunus,Sener, Ahmet,Ipekoglu, Alemdar Mustafa,Kollenz, Gert
, p. 221 - 224 (2007/10/03)
The 1H-pyrazole-3-carboxylic acid 2 or its remarkably stable acid chloride 3 can easily be converted into the corresponding ester or amide derivatives 4 or 5, respectively, from reaction with alcohols or N-nucleophiles. Pyrazolo[3,4-d]pyridazines 6a,b are obtained from cyclocondensation reactions of the pyrazoles 2 and 3, respectively, with phenylhydrazine or hydrazine hydrate, while 6c is formed in an one-pot procedure from the furan-2,3-dione 1 and hydrazine hydrate.
