18251-48-4Relevant academic research and scientific papers
Selective One-Pot Three-Step Cascade Reaction: From Aromatic Aldehydes to 2,2-Diphenylethanol Derivatives
Billamboz, Muriel,Imbs, Claire,Banaszak-Léonard, Estelle,Len, Christophe
supporting information, p. 835 - 843 (2017/06/23)
We report herein a green and scalable one-pot, three-step, pinacol-coupling-rearrangement-reduction cascade reaction useful for the formation of 2,2-diphenylethanol derivatives. The reaction is carried out in water in the presence of a commercially available and regenerable supported acid under moderate pressure. A dozen of aromatic aldehydes have been successfully submitted to the standard protocol giving the target 2,2-diarylethanol derivatives in good yield (70-85%).
Synthesis and structure-activity relationship studies of novel 2-diarylethyl substituted (2-carboxycycloprop-1-yl)glycines as high-affinity group II metabotropic glutamate receptor ligands.
Sorensen, Ulrik S,Bleisch, Thomas J,Kingston, Anne E,Wright, Rebecca A,Johnson, Bryan G,Schoepp, Darryle D,Ornstein, Paul L
, p. 197 - 205 (2007/10/03)
The major excitatory neurotransmitter in the central nervous system, (S)-glutamic acid , activates both ionotropic and metabotropic excitatory amino acid receptors. Its importance in connection to neurological and psychiatric disorders has directed great
