18251-51-9Relevant academic research and scientific papers
Radical Benzylation of Quinones via C-H Abstraction
Galloway, Jordan D.,Mai, Duy N.,Baxter, Ryan D.
, p. 12131 - 12137 (2019/10/02)
Herein we report the development of radical benzylation reactions of quinones using Selectfluor and catalytic Ag(I) initiators. The reaction is believed to proceed via a C-H abstraction mechanism after Ag(I)-mediated reduction of Selectfluor. This reaction occurs under mild conditions and is effective for a variety of quinones and radical precursors bearing primary benzylic carbons. The use of preformed Ag(4-OMePy)2NO3 as a catalyst proved effective in improving the reaction efficiency by reducing unwanted degradation pathways available to Selectfluor.
Transition-metal-free cross-dehydrogenative alkylation of pyridines under neutral conditions
Li, Xin,Wang, Hao-Yuan,Shi, Zhang-Jie
, p. 1704 - 1706 (2013/07/04)
A mild and efficient method has been developed for the direct dehydrogenative alkylation of unprotonated pyridine derivatives. The avoidance of using acids and transition-metals makes this protocol greener and more practical for the synthesis of substituted pyridines.
PROTEOMIMETIC COMPOUNDS AS INHIBITORS OF THE INTERACTION OF A NUCLEAR RECEPTOR WITH COACTIVATOR PEPTIDES
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Page/Page column 32, (2008/06/13)
The present invention relates to compounds, pharmaceutical compositions and methods which inhibit the binding of coactivator proteins in nuclear receptors, including estrogen receptors (alpha and/or beta), androgen receptors, thyroid receptors and peroxis
Helix mimetics as inhibitors of the interaction of the estrogen receptor with coactivator peptides
Becerril, Jorge,Hamilton, Andrew D.
, p. 4471 - 4473 (2008/03/27)
The short and curlies: A new α-helix mimetic based on a pyridylpyridone scaffold has been developed to bind to the estrogen receptor (ER) by mimicking the key leucine side chains of coactivator LXXLL boxes (L= leucine, X = any amino acid). These inhibitor
