182560-15-2Relevant academic research and scientific papers
Process for producing 4a-aryldecahydroisoquinoline derivatives
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, (2008/06/13)
The present invention provides a novel process for producing 4a-aryldecahydroisoquinoline compounds. The process is especially useful for preparing 4a-trans-6-oxo-aryldecahydroisoquinoline compounds.
Synthesis of trans-4a-aryl-6-oxodecahydroiso-quinolines
Kawamura, Kuniaki,Kawai, Koji,Miyamoto, Toru,Ooshima, Koji,Nagase, Hiroshi
, p. 267 - 283 (2007/10/03)
General and short synthesis of trans-4a-aryl-6-oxodecahydroiso-quinolines was described. In particular, the synthesis of 2-cyclopropylmethyl-4a-(3-hydroxyphenyl)-trans-6-oxodecahydroisoquinoline (12), one of the remarkably useful molecule as an opioid message structural part, was attained in only seven steps. The key step in this synthetic approach was 1,4-conjugate addition of aryl moiety to sterically hindered enones (2).
