137517-52-3

Upstream product

• 137517-55-6 3-((4aS,8aS)-2-Cyclopropylmethyl-6-methylene-octahydro-isoquinolin-4a-yl)-phenol 
• 182560-15-2 2-cyclopropylmethyl-6,6-ethylenedioxy-4a-(m-methoxyphenyl)-2,3,4,4a,5,6,7,8-octahydroisoquinoline 
• 73224-22-3 1-methyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine 
• 137517-51-2 trans-decahydro-4a-(3-methoxyphenyl)-6-methyleneisoquinoline 
• 137517-46-5 trans-phenyl octahydro-4a-(3-methoxyphenyl)-6-methylene-2(1H)-isoquinolinecarboxylate 
• 137539-89-0 trans-2-(cyclopropylmethyl)decahydro-4a-(3-methoxyphenyl)-6-methyleneisoquinoline 
• 137517-45-4 2,3,4,4a,5,6,7,8-octahydro-4a-(3-methoxyphenyl)-2-methyl-6-methyleneisoquinoline 

Relevant academic research and scientific papers

Synthesis of trans-4a-aryl-6-oxodecahydroiso-quinolines

General and short synthesis of trans-4a-aryl-6-oxodecahydroiso-quinolines was described. In particular, the synthesis of 2-cyclopropylmethyl-4a-(3-hydroxyphenyl)-trans-6-oxodecahydroisoquinoline (12), one of the remarkably useful molecule as an opioid message structural part, was attained in only seven steps. The key step in this synthetic approach was 1,4-conjugate addition of aryl moiety to sterically hindered enones (2).

Synthesis, Antinociceptive Activity, and Opioid Receptor Profiles of Substituted trans-3-(Decahydro- and Octahydro-4a-isoquinolinyl)phenols

A series of trans-3-(6- and 7-substituted-decahydro-4a-isoquinolinyl)phenols and trans-3-(octahydro-4a-isoquinolinyl)phenols have been synthesized as potential opioid analgesics.Using a combination of in vitro and in vivo test systems, the receptor profil