182567-73-3

Upstream product

• 158257-34-2 (S)-5-benzyl-1-benzyloxycarbonyl-4-hydroxy-2,5-dihydropyrrol-2-one 
• 55740-07-3 (4S)-4-benzyl-5-oxo-1,3-oxazolidine-3-carboxylic acid benzyl ester 
• 220931-41-9 (S)-4-Benzyl-5-[1-ethoxycarbonyl-meth-(E)-ylidene]-oxazolidine-3-carboxylic acid benzyl ester 
• 1161-13-3 N-Cbz-L-Phe 

Downstream Products

• 129029-32-9 (4S,5S)-5-Benzyl-2-oxo-4-hydroxypyrrolidine 
• 72155-48-7 (3S,4S)-4-tert-butoxycarbonylamino-3-hydroxy-5-phenylpentanoic acid 
• 109579-10-4 (4S,5R)-N-(((tert)-butyloxy)carbonyl)-5-benzyl-4-hydroxy-2-pyrrolidinone 

Relevant academic research and scientific papers

A novel Wittig reaction of oxazolidinones: Stereospecific synthesis of N-BOC-(3S,4S)-statine and N-BOC-(3S,4S)-AHPPA

Stereospecific synthesis of N-BOC-(3S,4S)-Statine and N-BOC-(3S,4S)- AHPPA is achieved via a novel Wittig reaction of oxazolidinones in an efficient manner.

An improved procedure to homochiral cyclic statines

Chiral tetramic acids were prepared in high yields by the reaction of N-protected amino acids with Meldrum's acid employing DCC as a carboxyl activating agent. Reduction or hydrogenation of these tetramic acids produced homochiral cyclic statines.