182617-59-0

Basic information

• Product Name: (S)-2-{(2S,3S)-2-[(S)-2-((S)-2-{(S)-2-Acetylamino-3-[4-(4,4-dimethoxy-3-oxo-butyl)-phenyl]-propionylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-3-methyl-pentanoylamino}-pentanedioic acid
• Synonyms: (S)-2-{(2S,3S)-2-[(S)-2-((S)-2-{(S)-2-Acetylamino-3-[4-(4,4-dimethoxy-3-oxo-butyl)-phenyl]-propionylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-3-methyl-pentanoylamino}-pentanedioic acid
• CAS NO: 182617-59-0
• Molecular Weight: 837.879
• Mol File: 182617-59-0.mol

Chemical Properties

• CAS DataBase Reference: (S)-2-{(2S,3S)-2-[(S)-2-((S)-2-{(S)-2-Acetylamino-3-[4-(4,4-dimethoxy-3-oxo-butyl)-phenyl]-propionylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-3-methyl-pentanoylamino}-pentanedioic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-{(2S,3S)-2-[(S)-2-((S)-2-{(S)-2-Acetylamino-3-[4-(4,4-dimethoxy-3-oxo-butyl)-phenyl]-propionylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-3-methyl-pentanoylamino}-pentanedioic acid(182617-59-0)
• EPA Substance Registry System: (S)-2-{(2S,3S)-2-[(S)-2-((S)-2-{(S)-2-Acetylamino-3-[4-(4,4-dimethoxy-3-oxo-butyl)-phenyl]-propionylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-3-methyl-pentanoylamino}-pentanedioic acid(182617-59-0)

Safety Data

• Hazardous Substances Data: 182617-59-0(Hazardous Substances Data)

Upstream product

• 182617-55-6 benzyl 4,4-dimethoxy-3-oxobutyrate 
• 6342-56-9 Pyruvic aldehyde dimethyl acetal 
• 182617-58-9 (S)-2-Acetylamino-3-[4-(4,4-dimethoxy-3-oxo-butyl)-phenyl]-propionic acid 

Relevant articles and documents

α-Dicarbonyls as 'non-charged' arginine-directed affinity labels. Novel synthetic routes to α-dicarbonyl analogs of the pp60(c-src) SH2 domain-targeted phosphopeptide Ac-Tyr(OPO3H2)-Glu-Glu-Ile-Glu

The phosphopeptide 1 is a potent inhibitor of pp60(c-src) SH2 domain mediated phosphoprotein interactions (IC50 ≤ 0.5 μM), but lacks cell permeability. The syntheses of its less charged analogs 2 and 3 are described, in which the arginine-binding phosphate group has been substituted with uncharged α-dicarbonyl moieties. The chemistry described here may be of general use for the synthesis of other α-dicarbonyl compounds.