182753-96-4Relevant academic research and scientific papers
Re-functionalization of 9-substituted isocolchicides via nucleophilic tele-substitution. A general synthesis of 11-alkyl(aryl)thioisocolchicides
Cavazza, Marino,Pietra, Francesco
, p. 1347 - 1351 (2007/10/03)
9-Substituted isocolchicides in methanol or dimethyl sulfoxide undergo ipso-substitution by sodium thiolates in mixture with the corresponding thiols, giving 9-alkyl(aryl)thio-substituted isocolchicides which are prone to in situ tele-substitution affording 11-alkyl(aryl)thio functionalized isocolchicides. Such C-11 activation by dicoordinated sulfur is used here for a general synthesis of 11-alkyl(aryl)thioisocolchicides.
