182758-72-1

Upstream product

• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 182967-41-5 (S)-2-(3,5-Dimethyl-pyrazole-1-carbonyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 105706-84-1 (S)-2-formyl-1-pyrrolidinecarboxylic acid,phenylmethyl ester 
• 143-33-9 sodium cyanide 

Downstream Products

• 72351-45-2 2-Hydroxy-2-(N-benzyloxycarbonylpyrrolidin-2-yl)-acetic acid 
• 72351-44-1 2-Hydroxy-2-(L-pyrrolidin-2-yl)acetic acid 

Relevant academic research and scientific papers

Poststatin, a new inhibitor of prolyl endopeptidase. VI. Endopeptidase inhibitory activity of poststatin analogues containing pyrrolidine ring

Several pyrrolidine-containing analogues of poststatin were synthesized and examined for their inhibitory activity against prolyl endopeptidase and cathepsin B in vitro. Replacement of the postine residue with 2-oxo-2-(2-pyrrolidinyl)acetic acid increased the selectivity and inhibitory activity against prolyl endopeptidase. Benzyloxycarbonyl-L-phenylalanyl-(S)-2-oxo-2-(2-pyrrolidinyl)acetyl -D-phenylalanine was about 46 times as active to prolyl endopeptidase as natural poststatin.