72351-45-2

Upstream product

• 72351-44-1 2-Hydroxy-2-(L-pyrrolidin-2-yl)acetic acid 
• 42116-21-2 2-benzyloxycarbonylsulfanyl-4,6-dimethyl-pyrimidine 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 501-53-1 benzyl chloroformate 
• 105706-84-1 (S)-2-formyl-1-pyrrolidinecarboxylic acid,phenylmethyl ester 
• 182967-41-5 (S)-2-(3,5-Dimethyl-pyrazole-1-carbonyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 182758-72-1 2-(Cyano-hydroxy-methyl)-pyrrolidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Poststatin, a new inhibitor of prolyl endopeptidase. VI. Endopeptidase inhibitory activity of poststatin analogues containing pyrrolidine ring

Several pyrrolidine-containing analogues of poststatin were synthesized and examined for their inhibitory activity against prolyl endopeptidase and cathepsin B in vitro. Replacement of the postine residue with 2-oxo-2-(2-pyrrolidinyl)acetic acid increased the selectivity and inhibitory activity against prolyl endopeptidase. Benzyloxycarbonyl-L-phenylalanyl-(S)-2-oxo-2-(2-pyrrolidinyl)acetyl -D-phenylalanine was about 46 times as active to prolyl endopeptidase as natural poststatin.

α-keto amide derivatives

The present invention discloses a new α-keto amide derivative or a salt thereof represented by the formula (1): STR1 wherein X represents (1) a peptide residue or amino acid residue in which the functional group may be protected, (2) a hydrogen atom or (3

Novel aminoglycoside derivatives

Novel aminoglycoside derivatives and their salts containing 2-deoxystreptamine moiety, of which the 1-amino group is acylated by a group represented by the formula: STR1 (wherein R is 4 to 6 membered heterocyclic group containing 1 to 2 nitrogen atoms whi