182816-16-6

Basic information

• Product Name: 2-fluoro-2-(4-isobutylphenyl)propyl acetate
• Synonyms: 2-fluoro-2-(4-isobutylphenyl)propyl acetate
• CAS NO: 182816-16-6
• Molecular Weight: 252.329
• Mol File: 182816-16-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-fluoro-2-(4-isobutylphenyl)propyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-2-(4-isobutylphenyl)propyl acetate(182816-16-6)
• EPA Substance Registry System: 2-fluoro-2-(4-isobutylphenyl)propyl acetate(182816-16-6)

Safety Data

• Hazardous Substances Data: 182816-16-6(Hazardous Substances Data)

Upstream product

• 127-08-2 potassium acetate 
• 182816-09-7 1-bromo-2-fluoro-2-(4-isobutylphenyl)propane 
• 34352-86-8 1-isobutyl-4-(prop-1-en-2-yl)benzene 

Downstream Products

• 180293-49-6 2-fluoro-2-[4-(2-methylpropyl)phenyl]propionic acid 
• 182816-19-9 2-fluoro-2-(4-isobutylphenyl)propanol 

Relevant articles and documents

Convenient routes to 2-aryl-2-fluoropropionic acids: Synthesis of monofluorinated analogues of (±)-ibuprofen, (±)-naproxen and related compounds

The synthesis of α-fluorinated arylpropionic acids 5 as analogues of the nonsteroidal anti-inflammatory agents (NSAIDs) flurbiprofen 1, ibuprofen 3 and naproxen 4 is accomplished by the oxidation of the corresponding primary alcohols 9. The latter are accessible on two different pathways showing their general applicability by variation of the aromatic moiety. Furthermore the influence of the fluorine substituent towards the conformation of the acid moiety in the crystal lattice is shown by comparative X-ray studies of compound 5c.