182822-15-7Relevant articles and documents
Synthesis and pharmacological properties of cardenolides substituted at the butenolide part
Staroske, Thomas,Hennig, Lothar,Welzel, Peter,Hofmann, Hans-Joerg,Mueller, Dietrich,Haeusler, Thomas,Sheldrick, William S.,Zillikens, Stefan,Gretzer, Britta,Pusch, Hermann,Glitsch, Helfried G.
, p. 12723 - 12744 (2007/10/03)
Deprotonation of the digitoxigenin lactone moiety with NaH in N-methylpyrrolidone yields and enolate that reacts at the 21- or 22-position depending on the electrophile. Lactone substituted derivatives of digitoxigenin have been prepared and their inhibition of the cardiac Na+ pump and the inotropic effect of some of the compounds have been studied. Structure-activity relationships are discussed in terms of the Holtje-Anzali model.