182865-71-0Relevant articles and documents
Stereoselective synthesis of Lewis-associated trisaccharides as E-selectin inhibitors
Imazaki, Naonori,Koike, Haruhiko,Miyauchi, Hiroshi,Hayashi, Masaji
, p. 2043 - 2048 (1996)
Three types of Lewis-associated trisaccharides [the Lea analogs, their epimers with respect to the fucose residue (the 1c-epi-Lea analogs), and the Le(x) analogs] were synthesized in a stereoselective manner. Not only the Lea analogs but also the 1c-epi-Lea analogs inhibited E-selectin-mediated neutrophil accumulation into pleural cavity in lipoteichoic acid-treated mice, with the trend being Lea > 1c-epi-Lea > Le(x).