18288-07-8Relevant academic research and scientific papers
Facile synthesis of 4H-chromene derivatives via base-mediated annulation of orffro-hydroxychalcones and 2-bromoallyl sulfones
Thadkapally, Srinivas,Kunjachan, Athira C.,Menon, Rajeev S.
, p. 16 - 21 (2016/04/05)
The cesium carbonate-mediated reaction of 2-bromoallyl sulfones and ortho-hydroxychalcones furnished 3-arylsulfonyl-4H-chromene derivatives in 58-67% yield (18 examples). 2-Bromoallyl sulfones functioned as synthetic surrogates for allenyl sulfones in the reaction.
Organocatalyzed michael-michael cascade reaction: Asymmetric synthesis of polysubstituted chromans
Jia, Zhen-Xin,Luo, Yong-Chun,Cheng, Xi-Na,Xu, Peng-Fei,Gu, Yu-Cheng
, p. 6488 - 6494 (2013/07/26)
An enantioselective cascade Michael-Michael reaction between chalcones enolates and nitromethane catalyzed by a bifunctional thiourea is developed. This reaction provides a mild but efficient approach to chiral benzopyrans bearing three consecutive stereocenters in high yields with excellent stereoselectivities, and the benzopyrans can be easily transformed to the corresponding tricyclic product.
