182884-17-9Relevant academic research and scientific papers
Highly enantioselective aryl additions of [AlAr3(thf)] to ketones catalyzed by a titanium(IV) catalyst of (S)-binol
Chen, Chien-An,Wu, Kuo-Hui,Gau, Han-Mou
, p. 5373 - 5376 (2007)
(Chemical Equation Presented) Chiral transfer: Novel asymmetric aryl transfers from [AlAr3(thf)] to a wide variety of ketones are catalyzed by an in situ generated titanium species with (S)-binol as the chiral ligand. The reaction affords terti
Enantioselective additions of aryltitanium tris(isopropoxide) to ketones: Structure of [(i-PrO)2Ti{μ-(S)-BINOLate}(μ-O-i-Pr)TiPh(O-i-Pr) 2], study of mechanistic and stereochemical insights
Wu, Kuo-Hui,Kuo, Yi-Yin,Chen, Chien-An,Huang, Yi-Ling,Gau, Han-Mou
, p. 1001 - 1008 (2013/05/08)
Aryl addition reactions of ArTi(O-i-Pr)3 to aromatic, heteroaromatic, or α,β-unsaturated ketones are described, producing tertiary alcohols in good to excellent enantioselectivities of up to 97% ee. The structure of the dititanium complex [(i-PrO)2Ti{μ-(S)-BINOLate} (μ-O-i-Pr)TiPh(O-i-Pr)2] [(S)-4] that simultaneously bears a chiral directing ligand and a nucleophile is reported. Complex (S)-4 possesses a pocket structure and has been illustrated as the key active species for addition reactions of both aldehydes and ketones. Mechanistic and stereochemical insights concerning addition reactions of organometallic reagents to organic carbonyls are rationalized based on the pocket structure and pocket size of (S)-4. Copyright
Facile synthetic entry into the 1,3-dihydro-3-methyl-3-phenyl-1,2-benziodoxole family of λ3-iodanes
Rabah, Ghada A.,Koser, Gerald F.
, p. 6453 - 6456 (2007/10/03)
The synthesis of a series of 1,3-dihydro-3-methyl-3-phenyl-1,2-benziodoxoles, 7, containing chloro, tosyloxy, acetoxy, trifluoroacetoxy and azido ligands and the optical resolution of 2-iodo-α-methylbenzhydrol, the starting material for the synthesis of 7, are reported.
