182884-20-4Relevant academic research and scientific papers
A New Ketyl Radical Probe. Dehalogenation of o-Halobenzophenone
Yamataka, Hiroshi,Yamaguchi, Kazuhiko,Takatsuka, Tsutomu,Hanafusa, Terukiyo
, p. 1157 - 1158 (1992)
The reactions of o-, m-, or p-bromobenzophenone and o-iodobenzophenone with various Grignard reagents were carried out in diethyl ether at 0 deg C.The product analysis showed that these halobenzophenones can be a good chemical probe to evaluate the electron-transfer ability of nucleophiles to the aromatic ketones.
Fluorinations of unsymmetrical diaryliodonium salts containing: Ortho -sidearms; Influence of sidearm on selectivity
Abudken, Ahmed M. H.,Hope, Eric G.,Singh, Kuldip,Stuart, Alison M.
, p. 6140 - 6146 (2020/10/30)
Activated aromatics were reacted with two different fluoroidoane reagents 1 and 2 in the presence of triflic acid to prepare only the para-substituted diaryliodonium salts. With fluoroiodane 1 the unsymmetrical diaryliodonium salts contained an ortho-propan-2-ol sidearm, whereas the alcohol sidearm was eliminated to form an ortho-styrene sidearm in the reaction with fluoroiodane 2. Only the diaryliodonium salts containing a styrene sidearm were fluorinated successfully to deliver para-fluorinated aromatics in good yields.
New hypervalent iodine reagents for electrophilic trifluoromethylation and their precursors: Synthesis, structure, and reactivity
Niedermann, Katrin,Welch, Jan M.,Koller, Raffael,Cvengro, Ján,Santschi, Nico,Battaglia, Philip,Togni, Antonio
scheme or table, p. 5753 - 5761 (2010/09/18)
Several new five- and a six-membered heterocyclic monochloroiodanes, including two cationic species, were synthesized. Three of which were used for the preparation of corresponding trifluoromethylation reagents. These compounds were characterized by X-ray crystallography for a comparative structural study. A reactivity study on the trifluoromethylation of para-toluenesulfonic acid has been conducted in order to compare initial rates. Compounds having a longer I-O bond display a higher reactivity.
A concise synthesis of ortho-iodobenzyl alcohols via addition of ortho-Iodophenyl grignard reagent to aldehydes and ketones
Cvengro, Alcohols Jan,Stolz, Daniel,Togni, Antonio
experimental part, p. 2818 - 2824 (2010/01/21)
A wide range of both secondary and tertiary ortho-iodobenzyl alcohols was synthesized via addition of ortho-iodophenyl Grignard reagents to aldehydes and ketones. Significant improvements in terms of yields were observed with ketones upon addition of CeCl3. The potential application of the target compounds as precursors for novel electrophilic trifluoromethylating reagents based on hypervalent iodine derivatives was demonstrated. Georg Thieme Verlag Stuttgart.
