182916-37-6

Basic information

• Product Name: (4-Benzyl-1-oxo-1H-phthalazin-2-yl)-acetic acid [1-methyl-3-oxo-but-(E)-ylidene]-hydrazide
• CAS NO: 182916-37-6
• Molecular Weight: 390.442
• Mol File: 182916-37-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4-Benzyl-1-oxo-1H-phthalazin-2-yl)-acetic acid [1-methyl-3-oxo-but-(E)-ylidene]-hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Benzyl-1-oxo-1H-phthalazin-2-yl)-acetic acid [1-methyl-3-oxo-but-(E)-ylidene]-hydrazide(182916-37-6)
• EPA Substance Registry System: (4-Benzyl-1-oxo-1H-phthalazin-2-yl)-acetic acid [1-methyl-3-oxo-but-(E)-ylidene]-hydrazide(182916-37-6)

Safety Data

• Hazardous Substances Data: 182916-37-6(Hazardous Substances Data)

Upstream product

• 132544-84-4 4-benzyl-1(2H)-oxophthalazin-2-acetic acid ethyl ester 
• 32003-14-8 4-benzyl-2H-phthalazin-1-one 
• 123-54-6 acetylacetone 
• 130090-87-8 2-(4-benzyl-1-oxophthalazin-2(1H)-yl)acetohydrazide 

Relevant articles and documents

Synthesis and biological activity of some 4-benzyl-1(2H)-phthalazinone derivatives

4-Benzylphthalazin-1(2H)-one (2) has been prepared by treating benzalphthalide (1) with hydrazine. Alkylation of 2 with ethyl chloroacetate furnishes the ester 3, which on reaction with hydrazine affords hydrazide 4. The reactions of 4 with aldehydes, ketones, arylsulphonyl chlorides, phenylisocyanate, phenylisothiocyanate, benzoyl chloride, acetylacetone and carbon disulphide are studied. Cyclization of thiosemicarbazide (7b) with sodium hydroxide gives triazole derivative 17. The alkylation, Mannich and Michael reactions with triazole 17 are studied. The structures of the synthesized compounds have been established by their elemental analysis and spectral data. All the new compounds have been tested for their antibacterial and fungicidal activities and some of them have been found to be biologically active.