182949-89-9

Usage

Type

Brominated derivative of dihydrocoumarin

Origin

Found in plants

Therapeutic and biological properties

studied for potential

Uses in research

for its antioxidant and anti-inflammatory properties, and potential role in the development of new medications for various conditions

Physical form

Yellow solid

Solubility

Soluble in organic solvents

Chemical structure

Benzene ring and pyran ring with a bromine atom attached.

Upstream product

• 846037-74-9 1-bromo-2-[2-(2-methoxy-ethoxymethoxy)-ethyl]-benzene 
• 1074-16-4 2-bromophenylethyl alcohol 
• 845302-47-8 1-bromo-2-[2-(methoxymethoxy)ethyl]benzene 

Downstream Products

• 1446491-74-2 C₉H₈Br₂O 
• 1812221-73-0 5-bromo-isochroman-1-one 

Relevant academic research and scientific papers

Catalytic Asymmetric [4 + 3] Annulation of C, N-Cyclic Azomethine Imines with Copper Allenylidenes

The first asymmetric decarboxylative [4 + 3] annulation of propargylic carbamates with C,N-cyclic azomethine imines has been developed successfully by a copper-N-heterocyclic carbine system. This strategy led to a series of optically active isoquinoline-f

Phosphane-Catalyzed [3+3] Annulation of C,N-Cyclic Azomethine Imines with Ynones: A Practical Method for Tricyclic Dinitrogen-Fused Heterocycles

A phosphane-catalyzed [3+3] annulation of azomethine imines with ynones has been developed. Under mild reaction conditions, the reaction proceeds smoothly to afford tricyclic dinitrogen-fused heterocyclic compounds in moderate to excellent yields with moderate to excellent stereoselectivies. Using a chiral phosphine as the catalyst, the reaction could work to give the cycloadduct in moderate yield with moderate enantioselectivity. (Figure presented.) .

CuBr2 catalyzed bromination/oxidation of isochromans to benzaldehyde derivatives

A series of isochromans were oxidized and brominated by using 1.2 equiv of CuBr2 in CH3CN at reflux to give the corresponding bromo benzaldehydes in moderate yields. A plausible mechanism for this transformation has been suggested.

Synthesis of chromanyl and dihydrobenzofuranyl piperazines

The synthesis of a series of regioisomeric chromanyl and dihydrobenzofuranyl piperazines is described.

New substituted isochromans

Isochromans with substituents in the aromatic ring are described. They are synthesised by cyclisation of related chloromethyl-2-phenylethyl ethers. The activated 1-position of the isochromans is essential for obtaining potential drugs.