1830-48-4

Upstream product

• 1003-83-4 2,2-dimethyl-4,7-dihydro-1,3-dioxepin 
• 927-77-5 n-propylmagnesium bromide 
• 7045-86-5 2-methyl-4,7-dihydro-1,3-dioxepine 

Downstream Products

• 1337991-95-3 2-(4-benzyloxy-3-fluorophenyl)-4-bromo-5-propyltetrahydropyran 
• 915943-81-6 C₂₅H₃₂O₃ 
• 915943-80-5 C₂₅H₃₃BrO₃ 

Relevant academic research and scientific papers

EFFICIENT AND REGIOCONTROLLED NICKEL(II)-CATALYZED ALKYLATION OF 2-ALKYL-1,3-DIOXEP-4-ENES BY GRIGNARD REAGENTS: A SIMPLE ROUTE TO ALLYLIC ALCOHOLS

The regio- and the stereochemistries of the NidppeCl2 catalyzed alkylation of 2-alkyl-1,3-dioxep-4-enes by Grignard reagents are not affected by the nature of the C2 substituent; in any case, allylic alcohols are the main reaction products and nearly pure Z isomers are almost quantitatively obtained when either secondary or tertiary Grignard reagents are used.A rationale for the reaction is proposed.

NICKEL(II)-CATALYZED ALKYLATION OF 2-METHYL-1,3-DIOXEP-4-ENE BY GRIGNARD REAGENTS: AN EFFICIENT AND SELECTIVE ROUTE TO ALLYLIC ALCOHOLS

Allylic alcohols are formed, in good yields, through the regiocontrolled Cl2Nidppe-catalyzed alkylation of 2-methyl-1,3-dioxep-4-ene by Grignard reagents .Highly pure Z alcohols arise when secondary and tertiary aliphatic Grignards are used.