183000-60-4

Usage

Uses

Used in Organic Synthesis:
t-Butyl 2-borono-4-methylbenzenesulfonamide is used as a reagent for the introduction of boron into organic molecules, facilitating the formation of carbon-carbon and carbon-heteroatom bonds. Its utility in this application is due to its ability to participate in various synthetic reactions, contributing to the creation of complex organic molecules.
Used in the Creation of Complex Organic Molecules:
In the field of synthetic chemistry, t-Butyl 2-borono-4-methylbenzenesulfonamide is employed as a key component in the synthesis of complex organic molecules. Its structural features, including the boron atom and the t-butyl group, make it a preferred choice for chemists looking to construct intricate molecular architectures.
Used in Chemical Reactions with Specific Reactivity and Selectivity:
The steric hindrance provided by the t-butyl group in t-Butyl 2-borono-4-methylbenzenesulfonamide is used to influence the reactivity and selectivity of the compound in chemical reactions. This feature is particularly important in reactions where precise control over the outcome is necessary, making the compound a valuable tool for achieving specific synthetic goals.

Upstream product

• 5419-55-6 Triisopropyl borate 
• 2849-81-2 N-t-butyl-p-toluenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of 1,2,4-triazole bearing 5-substituted biphenyl-2-sulfonamide derivatives as potential antihypertensive candidates

A series of novel 1,2,4-triazole bearing 5-substituted biphenyl-2- sulfonamide derivatives were designed and synthesized to develop new angiotensin II subtype 2 (AT2) receptor agonists as novel antihypertensive candidates. It was found that 14f (IC50 = 0.4 nM) and 15e (IC 50 = 5.0 nM) displayed potent AT2 receptor affinity and selectivity in binding assays. Biological evaluation in vivo suggested that 14f is obviously superior to that of reference drug losartan in RHRs, and meanwhile, 14f has no significant impact on heart rate. The interesting activities of these compounds may make them promising candidates as antihypertensive agents.

Factor xa inhibitors with aryl-amidines and derivatives, and prodrugs thereof

The present invention relates to a compound with aryl-amidines, particularly amidinoaryl-cyclopropanes, amidinoarylmethyl-pyrroles, amidinoaryl-benzenes, amidinoaryl-pyridines, or amindonoaryl-alanines, represented by formula (1), a pharmaceutically acceptable salt, a prodrug, a hydrate, a solvate or an isomer thereof, which are inhibitors of coagulation enzyme, factor Xa (FXa). The present invention also relates to a pharmaceutical composition containing the compound, and a method of using the same as an anticoagulant agent for treatment and prevention of thrombosis disorders.