183069-99-0Relevant academic research and scientific papers
Diastereoselective synthesis of α,α-disubstituted γ-carboxypyroglutamates via Sm(III)-azomethine ylide cycloadditions
Alvarez-Ibarra, Carlos,Csaky, Aurelio G.,De Silanes, Isabel Lopez,Quiroga, M. Luz
, p. 479 - 484 (1997)
Sm(III)-azomethine ylides 2 have been generated from ketones 1. Cycloaddition of ylides 2 with α,β-unsaturated esters 3 through a transition state chelation-controlled by the metal allowed for the asymmetric synthesis of γ-carboxypyroglutamates having a quaternary α-carbon that are potentially useful in the synthesis of neuroprotective agents.
On the acylation reactions of aza-allyl carbanions derived from N-[bis(methylthio)methylene]glycine ethyl ester and N-[bis(methylthio)methylene]benzylamine
Alvarez-Ibarra, Carlos,Csaky, Aurelio G.,Martinez-Santos, Elena,Quiroga, Maria L.
, p. 3679 - 3692 (2007/10/03)
New aspects of the acylation reaction of the aza-allyl anions derived from 1 and 2 have been studied. Under suitable reaction conditions, osazoles 5, α,α-disubstituted α-acyla-amino acid derivatives 3, and α,β-didehydroamino acid derivatives 7 can be prep
