183129-83-1

Upstream product

• 147427-38-1 4-(4-hexyl-phenyl)-butyric acid 
• 64779-08-4 4-(4-hexyl-phenyl)-4-oxo-butyric acid 
• 1077-16-3 hexylbenzene 
• 142-61-0 Hexanoyl chloride 
• 7492-40-2 4-phenylbutyl acetate 

Downstream Products

• 162357-97-3 4-(4-hexylphenyl)-1-iodobutane 
• 1026505-04-3 N-[5-(4-hexyl-phenyl)-1,1-bis-hydroxymethyl-pentyl]-acetamide 
• 162357-98-4 diethyl 2-acetamido-2-[4-(4-hexylphenyl)butyl]malonate 
• 162359-49-1 2-acetamido-1,3-diacetoxy-2-[4-(4-hexylphenyl)butyl]propane 
• 162357-96-2 4-(4-hexylphenyl)butyl p-toluenesulfonate 
• 117280-37-2 [5-(2-Chloro-phenyl)-7-[2-(4-hexyl-phenyl)-ethyl]-1,3-dihydro-thieno[2,3-e][1,4]diazepin-(2Z)-ylidene]-hydrazine 
• 117280-36-1 5-(2-chlorophenyl)-7-[2-(4-n-hexylphenyl)ethyl]-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepine-2-thione 
• 117280-35-0 5-(2-chlorophenyl)-7-[2-(4-n-hexylphenyl)ethyl]-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepin-2-one 
• 183130-13-4 2-Amino-N-{3-(2-chloro-benzoyl)-5-[2-(4-hexyl-phenyl)-ethyl]-thiophen-2-yl}-acetamide 
• 1027263-85-9 N-{3-(2-Chloro-benzoyl)-5-[2-(4-hexyl-phenyl)-ethyl]-thiophen-2-yl}-2-iodo-acetamide 
• 183130-02-1 2-Chloro-N-{3-(2-chloro-benzoyl)-5-[2-(4-hexyl-phenyl)-ethyl]-thiophen-2-yl}-acetamide 
• 183129-95-5 {2-Amino-5-[2-(4-hexyl-phenyl)-ethyl]-thiophen-3-yl}-(2-chloro-phenyl)-methanone 
• 183129-87-5 4-(4-Hexyl-phenyl)-butyraldehyde 

Relevant academic research and scientific papers

Synthesis and immunosuppressive activity of 2-substituted 2- aminopropane-1,3-diols and 2-aminoethanols

A series of 2-substituted 2-aminopropane-1,3-diols was synthesized and evaluated for their lymphocyte-decreasing effect and immunosuppressive effect on rat skin allograft. A phenyl ring was introduced into the alkyl chain of the lead compound 3, which is an immunosuppressive agent structurally simplified from myriocin (1, ISP-I) via compound 2. The potency of the various compounds was dependent upon the position of the phenyl ring within the alkyl side chain. The most suitable length between the quaternary carbon atom and the phenyl ring was two carbon atoms. 2-Substituted 2-aminoethanols were successively synthesized and evaluated for their T-cell-decreasing effect and immunosuppressive effect using a popliteal lymph node gain assay in rats. The absolute configuration at the quaternary carbon affected the activity, and the (pro-S)-hydroxymethyl group of compound 6 was essential for potent immunosuppressive activity. Favorable substituents for the (pro-R)- hydroxymethyl group of 6 were hydroxyalkyl (hydroxyethyl and hydroxypropyl) or lower alkyl (methyl and ethyl) groups. 2-Amino-2-[2-(4- octylphenyl)ethyl]propane-1,3-diol hydrochloride (6, FTY720) was found to possess considerable activity and is expected to be useful as an immunosuppressive drug for organ transplantation.

Structural optimization of 4-(2-chlorophenyl)-9-methyl-6H-thieno [3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines as antagonists for platelet activating factor: Pharmacological contribution of substituents at the 2- and 6-positions of a condensed ring system

A series of 4-(2-chlorophenyl)-9-methyl-6H-thieno [3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine derivatives bearing substituents at the 2- and 6-positions were synthesized, and evaluated in vitro for their inhibitory activity on rabbit platelet aggregation induced by platelet activating factor (PAF) and in vivo for their preventing effect on PAF-induced mortality in mice. The length of alkyl or arylalkyl side chain at the 2-position was responsible for enhancing the affinity for the PAF receptor. The simultaneous substitution at both the 2- and 6-positions resulted in a successful separation of the affinity for the PAF receptor from that for the benzodiazepine (BZ) receptor. Thus, (±)-4-(2-chlorophenyl)-2-[2-(4-isobutylphenyl)ethyl]- 6,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4] diazepine (Y-24180) was confirmed to be a specific antagonist for the PAF receptor and is currently under clinical trials.