183133-95-1

Upstream product

• 115437-18-8 7-triethylsilyl-10-deacetylbaccatin III 
• 160084-70-8 4α-acetoxy-2α-benzoyIoxy-5β,20-epoxy-1β,13α-dihydroxy-10β-methoxy-9-oxo-7β-triethylsilyloxy-11-taxene 
• 183133-97-3 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-10β-methoxy-9-oxo-1β,13α,7β-trihydroxy-11-taxene 
• 183133-94-0 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene 
• 155396-69-3 (2R,4S,5R)-(2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid 
• 32981-86-5 10-deacetylbaccatin III 
• 1432613-35-8 7,10-di-O-1,3-benzodithiolan-2-yl-10-DAB 
• 1432613-36-9 7,10-di-O-1,3-dithian-2-yl-10-DAB 
• 1432613-38-1 (2α,5β,7β,10β,13α)-4-acetoxy-13-{(2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxy}-1-hydroxy-7,10-di-O-1,3-benzodithiolan-2-yl-9-oxo-5,20-epoxy-tax-11-en-2-yl benzoate 
• 1432613-43-8 10-O-methyl-7-O-1,3-benzodithiolan-2-yl-10-DAB 
• 1432613-39-2 C₅₇H₆₇NO₁₅S₄ 
• 1432613-37-0 C₃₇H₄₈O₁₀S₄ 
• 158830-38-7 C₅₁H₅₉NO₁₅ 
• 1432613-40-5 C₅₉H₇₁NO₁₅S₄ 

Downstream Products

• 183133-96-2 carbazitaxel 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF CABAZITAXEL AND ITS SOLVATES

The present disclosure provides anisole and benzyl alcohol solvates of cabazitaxel and methods of their production. The solvates may be characterized by powder x-ray diffraction patterns. The present disclosure also provides methods for the synthesis of cabazitaxel.

NOVEL METHOD FOR PREPARING CABAZITAXEL FROM 10-DEACETYLBACCATIN III IN HIGH YIELD, AND NOVEL INTERMEDIATE THEREFOR

The present invention relates to a novel method for preparing cabazitaxel from 10-deacetylbaccatin III, and a novel intermediate therefor, and more specifically, to: a method which allows cabazitaxel to be more easily prepared in a high yield and in a high purity within a short time compared with a conventional method by preparing cabazitaxel via a novel intermediate using 10-deacetylbaccatin III as a starting material, and thus is suitable for industrial mass production; and a novel intermediate therefor.

PROCESS FOR CABAZITAXEL, AND INTERMEDIATES THEREOF

The present invention relates to processes for making cabazitaxel, cabazitaxel analogues and intermediates thereof. The invention provides novel compounds useful in the synthesis of cabazitaxel.

PROCESS FOR MAKING AN INTERMEDIATE OF CABAZITAXEL

A novel process of making 7,10-dialkyl-10-DAB of formula (I) which is useful as a key intermediate for the preparation of cabazitaxel, comprises selective elaboration of positions 7 and 10 of 10-deacetylbaccatin III.