183181-98-8

Upstream product

• 542-69-8 1-iodo-butane 
• 139119-52-1 1-benzoyl-2(S)-tert-butyl-3-methylperhydropyrimidin-4-one 
• 98-88-4 benzoyl chloride 
• 143870-65-9 1-benzoyl-2(S)-tert-butyl-6(S)-carboxy-perhydropyrimidin-4-one 
• 143870-67-1 1-benzoyl-2(S)-tert-butyl-3-methyl-2,3-dihydro-4(1H)-pyrimidin-4-one 
• 143870-66-0 1-benzoyl-2(S)-tert-butyl-2,3-dihydro-4(1H)-pyrimidin-4-one 

Downstream Products

• 183182-05-0 (R)-(+)-α-n-butyl-β-aminopropionic acid 
• 183182-02-7 (2S,5S)-1-Benzoyl-5-butyl-2-tert-butyl-3-methyl-tetrahydro-pyrimidin-4-one 
• 68019-25-0 (S)-(+)-α-methyl-α-n-butyl-β-aminopropionic acid 
• 183182-08-3 (S)-2-(aminomethyl)hexanoic acid 

Relevant academic research and scientific papers

Enantioselective synthesis of β-amino acids. 7. Preparation of enantiopure α-substituted β-amino acids from 1-benzoyl-2(S)-tert-butyl-3-methylperhydropyrimidin-4-one

Inexpensive natural α-amino acid L-asparagine was efficiently converted to either (R)- or (S)-α-alkylated β-amino acids in enantiomerically pure state. The key intermediate in this protocol is the enantiopure N,N-acetal pyrimidinone (S)-1, a masked chiral derivative of β-alanine.