183182-04-9

Upstream product

• 143870-65-9 1-benzoyl-2(S)-tert-butyl-6(S)-carboxy-perhydropyrimidin-4-one 
• 139119-52-1 1-benzoyl-2(S)-tert-butyl-3-methylperhydropyrimidin-4-one 
• 143870-67-1 1-benzoyl-2(S)-tert-butyl-3-methyl-2,3-dihydro-4(1H)-pyrimidin-4-one 
• 143870-66-0 1-benzoyl-2(S)-tert-butyl-2,3-dihydro-4(1H)-pyrimidin-4-one 
• 98-88-4 benzoyl chloride 
• 183182-00-5 1-benzoyl-(2S)-tert-butyl-3-methyl-(5R)-benzylperhydropyrimidin-4-one 

Downstream Products

• 131683-27-7 (S)-(–)-β²-homophenylalanine 
• 210345-90-7 (S)-2-(Benzoylamino-methyl)-3-phenyl-propionic acid 

Relevant academic research and scientific papers

Enantioselective synthesis of β-amino acids. 7. Preparation of enantiopure α-substituted β-amino acids from 1-benzoyl-2(S)-tert-butyl-3-methylperhydropyrimidin-4-one

Inexpensive natural α-amino acid L-asparagine was efficiently converted to either (R)- or (S)-α-alkylated β-amino acids in enantiomerically pure state. The key intermediate in this protocol is the enantiopure N,N-acetal pyrimidinone (S)-1, a masked chiral derivative of β-alanine.